Age-related alterations in histone deacetylase expression in Purkinje neurons of ethanol-fed rats

•Purkinje neurons contain Class I histone deacetylases (HDACs) 2, 3 and Class IIb HDACs 4 and 7.•Densities of HDACs 2, 3, and 7+ Purkinje neurons decrease significantly with age in adult Fischer 344 rats.•Density of phosphorylated HDAC 4, 5, and 7 significantly increases with age as does nuclear loc...

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Veröffentlicht in:	Brain research 2017-11, Vol.1675, p.8-19
Hauptverfasser:	Khurana, Abhilasha, Dlugos, Cynthia A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - drug effects Aging - metabolism Alcohol Drinking - metabolism Alcohol Drinking - pathology Animals Cerebellum:Histone acetylation Chronic ethanol Ethanol - administration & dosage Gene Expression Regulation, Enzymologic Histone deacetylases Histone Deacetylases - biosynthesis Histone Deacetylases - genetics Male Purkinje Cells - drug effects Purkinje Cells - enzymology Purkinje Cells - pathology Purkinje neuron Rats Rats, Inbred F344
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