Ascorbic acid prevents zinc oxide nanoparticle–induced intracellular oxidative stress and inflammatory responses

Exposure to zinc oxide nanoparticles (ZnO NPs) promotes acute pulmonary toxicity through oxidative stress and inflammation. Furthermore, dissolved zinc from ZnO NPs induces the formation of intracellular reactive oxygen species (ROS). We previously reported that supplemental ascorbic acid (AA) inhib...

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Veröffentlicht in:	Toxicology and industrial health 2017-09, Vol.33 (9), p.687-695
Hauptverfasser:	Fukui, Hiroko, Iwahashi, Hitoshi, Nishio, Keiko, Hagihara, Yoshihisa, Yoshida, Yasukazu, Horie, Masanori
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Antioxidants Antioxidants - pharmacology Ascorbic acid Ascorbic Acid - pharmacology Biocompatibility Chelation Cytotoxicity Humans Inflammation Intracellular Lung carcinoma Metal Nanoparticles - toxicity Nanoparticles Oxidative stress Oxidative Stress - drug effects Particle Size Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Studies Toxicity Zinc oxide Zinc Oxide - toxicity Zinc oxides
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