A protective role of IRF3 and IRF7 signalling downstream TLRs in the development of vein graft disease via type I interferons

Background Toll like receptors (TLR) play an important role in vein graft disease (VGD). Interferon regulatory factors (IRF) 3 and 7 are the transcriptional regulators of type I interferons (IFN) and type I IFN responsive genes and are downstream factors of TLRs. Relatively little is known with rega...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of internal medicine 2017-12, Vol.282 (6), p.522-536
Hauptverfasser:	Simons, K. H., Peters, H. A. B., Jukema, J. W., Vries, M. R., Quax, P. H. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone marrow Cell activation Cytokines Cytokines - metabolism Gene Expression Regulation Graft Occlusion, Vascular - genetics Graft Occlusion, Vascular - metabolism Grafting Grafts Humans In vitro methods and tests In Vitro Techniques Inflammation Interferon Interferon regulatory factor Interferon regulatory factor 3 Interferon regulatory factor 7 Interferon Regulatory Factor-3 - metabolism Interferon Regulatory Factor-7 - metabolism Interferon Type I - metabolism Macrophages Macrophages - metabolism Male Mice Receptors Regulators Rodents Signal Transduction - genetics Signaling Smooth muscle Surgery Thickening TLR3 protein TLR4 protein toll like receptor Toll-like receptors Toll-Like Receptors - metabolism Transcription type I interferon Vascular Remodeling vascular remodelling vein graft disease Veins & arteries Wall thickness
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!