Tumor necrosis factor‐alpha inhibits osteogenic differentiation of pre‐osteoblasts by downregulation of EphB4 signaling via activated nuclear factor‐kappaB signaling pathway

Background and Objective The majority of experiments show that tumor necrosis factor‐alpha (TNF‐α) inhibits osteogenic differentiation of mesenchymal stem cells and pre‐osteoblasts by activated nuclear factor‐kappaB (NF‐κB) signaling. However, the underlying mechanisms by which NF‐κB signaling inhib...

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Veröffentlicht in:	Journal of periodontal research 2018-02, Vol.53 (1), p.66-72
Hauptverfasser:	Wang, L. M., Zhao, N., Zhang, J., Sun, Q. F., Yang, C. Z., Yang, P. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Bone sialoprotein Cbfa-1 protein Dentistry EphB4 signaling Kinases Mesenchyme Necrosis NF-κB protein NF‐κB signaling Osteoblastogenesis Osteoblasts osteogenic differentiation Osteopontin Polymerase chain reaction Pyrrolidine dithiocarbamate Reverse transcription Signal transduction Skin & tissue grafts Stem cell transplantation Stem cells TNF‐α Tumor necrosis factor-TNF Tumor necrosis factor-α
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