Hepatitis C virus down-regulates SERPINE1/PAI-1 expression to facilitate its replication

Identification of host factors involved in viral replication is critical for understanding the molecular mechanism of viral replication and pathogenesis. Genes differentially expressed in HuH-7 cells with or without a hepatitis C virus (HCV) sub-genomic replicon were screened by microarray analysis....

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Veröffentlicht in:	Journal of general virology 2017-09, Vol.98 (9), p.2274-2286
Hauptverfasser:	Yang, Chee-Hing, Li, Hui-Chun, Ku, Tzu-Shan, Wu, Pi-Ching, Yeh, Yung-Ju, Cheng, Ju-Chien, Lin, Teng-Yi, Lo, Shih-Yen
Format:	Artikel
Sprache:	eng
Schlagworte:	Down-Regulation Hepacivirus - genetics Hepacivirus - physiology Hepatitis C - genetics Hepatitis C - metabolism Hepatitis C - virology Host-Pathogen Interactions Humans Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - metabolism Signal Transduction Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Virus Replication
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