Newcastle disease virus mediates pancreatic tumor rejection via NK cell activation and prevents cancer relapse by prompting adaptive immunity

Pancreatic cancer is the 8th most common cause of cancer‐related deaths worldwide and the tumor with the poorest prognosis of all solid malignancies. In 1957, it was discovered that Newcastle disease virus (NDV) has oncolytic properties on tumor cells. To study the oncolytic properties of NDV in pan...

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Veröffentlicht in:	International journal of cancer 2017-12, Vol.141 (12), p.2505-2516
Hauptverfasser:	Schwaiger, Theresa, Knittler, Michael R, Grund, Christian, Roemer‐Oberdoerfer, Angela, Kapp, Joachim‐Friedrich, Lerch, Markus M, Mettenleiter, Thomas C, Mayerle, Julia, Blohm, Ulrike
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Adenocarcinoma Animals Antitumor activity anti‐tumor immunity Cancer Cell activation Cell Line, Tumor Cytotoxicity Humans Immune response Immunity (Disease) Immunogenicity Implantation Killer Cells, Natural - metabolism Lymphocyte Activation Lymphocytes T Medical research Metastases Mice Natural killer cells Neoplasm Recurrence, Local - prevention & control Newcastle disease Newcastle Disease Virus Newcastle disease virus - immunology Oncolysis Oncolytic Virotherapy Oncolytic Viruses - immunology orthotopic tumor model Pancreatic cancer Pancreatic Neoplasms - immunology Pancreatic Neoplasms - pathology Prognosis T cell receptors T-Lymphocytes, Helper-Inducer - metabolism Tumor cell lines Tumor cells Tumors virotherapy Viruses Xenograft Model Antitumor Assays
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