On the relevance of genotoxicity for fish populations I: effects of a model genotoxicant on zebrafish ( Danio rerio) in a complete life-cycle test
Genotoxicity may be detected in surface waters by means of various genotoxicity assays. In order to enable an ecotoxicological assessment of the consequences of such genotoxic potential for fish populations, a complete life-cycle test with zebrafish ( Danio rerio) and the model genotoxicant 4-nitroq...
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| Veröffentlicht in: | Aquatic toxicology 2004-05, Vol.68 (1), p.13-26 |
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| creator | Diekmann, Markus Hultsch, Veit Nagel, Roland |
| description | Genotoxicity may be detected in surface waters by means of various genotoxicity assays. In order to enable an ecotoxicological assessment of the consequences of such genotoxic potential for fish populations, a complete life-cycle test with zebrafish (
Danio rerio) and the model genotoxicant 4-nitroquinoline-1-oxide (NQO) was conducted. Zebrafish (f
1) were continuously exposed to NQO (i.e. 0.1, 0.3, 1.1, 2.9, and 14.6
μg/l, respectively) from fertilised eggs until sexual maturity. In addition to reproduction studies in the f
1-generation, f
2-fish were exposed to NQO during the first 6 weeks of development. Up to 2.9
μg/l NQO, fish did not display differences in survival and growth (
P |
| doi_str_mv | 10.1016/j.aquatox.2004.01.020 |
| format | Article |
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Danio rerio) and the model genotoxicant 4-nitroquinoline-1-oxide (NQO) was conducted. Zebrafish (f
1) were continuously exposed to NQO (i.e. 0.1, 0.3, 1.1, 2.9, and 14.6
μg/l, respectively) from fertilised eggs until sexual maturity. In addition to reproduction studies in the f
1-generation, f
2-fish were exposed to NQO during the first 6 weeks of development. Up to 2.9
μg/l NQO, fish did not display differences in survival and growth (
P<0.05). A NQO concentration of 14.6
μg/l, however, was lethal. Female fish exposed to all NQO concentrations up to 2.9
μg/l displayed a significant reduction in egg production (
P<0.05). A mathematical simulation revealed that exposure to weak concentrations of NQO is leading to an elevated extinction risk.</description><identifier>ISSN: 0166-445X</identifier><identifier>EISSN: 1879-1514</identifier><identifier>DOI: 10.1016/j.aquatox.2004.01.020</identifier><identifier>PMID: 15110466</identifier><identifier>CODEN: AQTODG</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>4-Nitroquinoline-1-oxide ; 4-Nitroquinoline-1-oxide - toxicity ; Agnatha. Pisces ; Analysis of Variance ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biological and medical sciences ; Body Weights and Measures ; Computer Simulation ; Danio rerio ; Dose-Response Relationship, Drug ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; Freshwater ; Fundamental and applied biological sciences. Psychology ; Gas Chromatography-Mass Spectrometry ; Growth - drug effects ; Life-cycle test ; Mutagenicity Tests ; Mutagens - toxicity ; Population ; Reproduction - drug effects ; Toxicity Tests, Chronic ; Zebrafish ; Zebrafish - genetics ; Zebrafish - growth & development</subject><ispartof>Aquatic toxicology, 2004-05, Vol.68 (1), p.13-26</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-306ade021bd17251a19b38adb6bdbb4f40a06165fa548284f16c3f3fe96e6e663</citedby><cites>FETCH-LOGICAL-c453t-306ade021bd17251a19b38adb6bdbb4f40a06165fa548284f16c3f3fe96e6e663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.aquatox.2004.01.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15745472$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15110466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diekmann, Markus</creatorcontrib><creatorcontrib>Hultsch, Veit</creatorcontrib><creatorcontrib>Nagel, Roland</creatorcontrib><title>On the relevance of genotoxicity for fish populations I: effects of a model genotoxicant on zebrafish ( Danio rerio) in a complete life-cycle test</title><title>Aquatic toxicology</title><addtitle>Aquat Toxicol</addtitle><description>Genotoxicity may be detected in surface waters by means of various genotoxicity assays. In order to enable an ecotoxicological assessment of the consequences of such genotoxic potential for fish populations, a complete life-cycle test with zebrafish (
Danio rerio) and the model genotoxicant 4-nitroquinoline-1-oxide (NQO) was conducted. Zebrafish (f
1) were continuously exposed to NQO (i.e. 0.1, 0.3, 1.1, 2.9, and 14.6
μg/l, respectively) from fertilised eggs until sexual maturity. In addition to reproduction studies in the f
1-generation, f
2-fish were exposed to NQO during the first 6 weeks of development. Up to 2.9
μg/l NQO, fish did not display differences in survival and growth (
P<0.05). A NQO concentration of 14.6
μg/l, however, was lethal. Female fish exposed to all NQO concentrations up to 2.9
μg/l displayed a significant reduction in egg production (
P<0.05). A mathematical simulation revealed that exposure to weak concentrations of NQO is leading to an elevated extinction risk.</description><subject>4-Nitroquinoline-1-oxide</subject><subject>4-Nitroquinoline-1-oxide - toxicity</subject><subject>Agnatha. Pisces</subject><subject>Analysis of Variance</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Body Weights and Measures</subject><subject>Computer Simulation</subject><subject>Danio rerio</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Growth - drug effects</subject><subject>Life-cycle test</subject><subject>Mutagenicity Tests</subject><subject>Mutagens - toxicity</subject><subject>Population</subject><subject>Reproduction - drug effects</subject><subject>Toxicity Tests, Chronic</subject><subject>Zebrafish</subject><subject>Zebrafish - genetics</subject><subject>Zebrafish - growth & development</subject><issn>0166-445X</issn><issn>1879-1514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAURi0EotPCI4C8AZVFgm_iOBk2CJW_SpW6AYmd5TjX1CMnTm2nYngMnhgPE6nsai-88PnuZ_kQ8gJYCQzE212pbheV_K-yYoyXDEpWsUdkA127LaAB_phsMicKzpsfJ-Q0xh3Lq-Lbp-Qk3wPjQmzIn-uJphukAR3eqUkj9Yb-xMnnyVbbtKfGB2psvKGznxenkvVTpJfvKBqDOsUDr-joB3T3OTUl6if6G_ug_mXP6Uc1WZ9rgvVvqJ1yRvtxdpiQOmuw0HvtkCaM6Rl5YpSL-Hw9z8j3z5--XXwtrq6_XF58uCo0b-pU1EyoAVkF_QBt1YCCbV93auhFP_Q9N5wpJkA0RjW8qzpuQOja1Aa3AvMW9Rl5fZw7B3-75GI52qjROTWhX6KEbc2ZqOBhUEDH2vYwsTmCOvgYAxo5BzuqsJfA5MGa3MnVmjxYkwxktpZzL9eCpR9xuE-tmjLwagVU1MqZkE3Z-B_X8oa3VebeHznM_3ZnMcioLWargw1Zlhy8feApfwG4TrnT</recordid><startdate>20040528</startdate><enddate>20040528</enddate><creator>Diekmann, Markus</creator><creator>Hultsch, Veit</creator><creator>Nagel, Roland</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7TV</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H96</scope><scope>L.G</scope><scope>H97</scope></search><sort><creationdate>20040528</creationdate><title>On the relevance of genotoxicity for fish populations I: effects of a model genotoxicant on zebrafish ( Danio rerio) in a complete life-cycle test</title><author>Diekmann, Markus ; Hultsch, Veit ; Nagel, Roland</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-306ade021bd17251a19b38adb6bdbb4f40a06165fa548284f16c3f3fe96e6e663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>4-Nitroquinoline-1-oxide</topic><topic>4-Nitroquinoline-1-oxide - toxicity</topic><topic>Agnatha. Pisces</topic><topic>Analysis of Variance</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Body Weights and Measures</topic><topic>Computer Simulation</topic><topic>Danio rerio</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Freshwater</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Growth - drug effects</topic><topic>Life-cycle test</topic><topic>Mutagenicity Tests</topic><topic>Mutagens - toxicity</topic><topic>Population</topic><topic>Reproduction - drug effects</topic><topic>Toxicity Tests, Chronic</topic><topic>Zebrafish</topic><topic>Zebrafish - genetics</topic><topic>Zebrafish - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diekmann, Markus</creatorcontrib><creatorcontrib>Hultsch, Veit</creatorcontrib><creatorcontrib>Nagel, Roland</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 2: Ocean Technology, Policy & Non-Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><jtitle>Aquatic toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diekmann, Markus</au><au>Hultsch, Veit</au><au>Nagel, Roland</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On the relevance of genotoxicity for fish populations I: effects of a model genotoxicant on zebrafish ( Danio rerio) in a complete life-cycle test</atitle><jtitle>Aquatic toxicology</jtitle><addtitle>Aquat Toxicol</addtitle><date>2004-05-28</date><risdate>2004</risdate><volume>68</volume><issue>1</issue><spage>13</spage><epage>26</epage><pages>13-26</pages><issn>0166-445X</issn><eissn>1879-1514</eissn><coden>AQTODG</coden><abstract>Genotoxicity may be detected in surface waters by means of various genotoxicity assays. In order to enable an ecotoxicological assessment of the consequences of such genotoxic potential for fish populations, a complete life-cycle test with zebrafish (
Danio rerio) and the model genotoxicant 4-nitroquinoline-1-oxide (NQO) was conducted. Zebrafish (f
1) were continuously exposed to NQO (i.e. 0.1, 0.3, 1.1, 2.9, and 14.6
μg/l, respectively) from fertilised eggs until sexual maturity. In addition to reproduction studies in the f
1-generation, f
2-fish were exposed to NQO during the first 6 weeks of development. Up to 2.9
μg/l NQO, fish did not display differences in survival and growth (
P<0.05). A NQO concentration of 14.6
μg/l, however, was lethal. Female fish exposed to all NQO concentrations up to 2.9
μg/l displayed a significant reduction in egg production (
P<0.05). A mathematical simulation revealed that exposure to weak concentrations of NQO is leading to an elevated extinction risk.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15110466</pmid><doi>10.1016/j.aquatox.2004.01.020</doi><tpages>14</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 4-Nitroquinoline-1-oxide 4-Nitroquinoline-1-oxide - toxicity Agnatha. Pisces Analysis of Variance Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Body Weights and Measures Computer Simulation Danio rerio Dose-Response Relationship, Drug Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Freshwater Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry Growth - drug effects Life-cycle test Mutagenicity Tests Mutagens - toxicity Population Reproduction - drug effects Toxicity Tests, Chronic Zebrafish Zebrafish - genetics Zebrafish - growth & development |
| title | On the relevance of genotoxicity for fish populations I: effects of a model genotoxicant on zebrafish ( Danio rerio) in a complete life-cycle test |
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