IL-1β suppresses nephronectin expression in osteoblasts via ERK1/2 and JNK

Nephronectin (Npnt), an extracellular matrix protein, is considered to play critical roles in development of various tissues and their functions. In basic science experiments, we found that interleukin-1β (IL-1β), well known to have an important role in inflammatory response, inhibited Npnt gene exp...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-11, Vol.493 (1), p.773-775
Hauptverfasser:	Iezumi, Yuka, Yamada, Atsushi, Minami, Erika, Ikehata, Mikiko, Yoshida, Yuko, Kato, Tadashi, Morimura, Naoko, Ogata, Hiroaki, Sakashita, Akiko, Iijima, Takehiko, Chikazu, Daichi, Kamijo, Ryutaro
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Down-Regulation - physiology Extracellular Matrix Proteins - immunology Gene Expression Regulation - immunology IL-1β Interleukin-1beta - immunology MAP Kinase Signaling System - immunology Mice Nephronectin Osteoblasts Osteoblasts - immunology
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