Uncovering the mystery of opposite circadian rhythms between mouse and human leukocytes in humanized mice

Many immune parameters show circadian rhythms during the 24-hour day in mammals. The most striking circadian oscillation is the number of circulating immune cells that display an opposite rhythm between humans and mice. The physiological roles and mechanisms of circadian variations in mouse leukocyt...

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Veröffentlicht in:	Blood 2017-11, Vol.130 (18), p.1995-2005
Hauptverfasser:	Zhao, Yue, Liu, Min, Chan, Xue Ying, Tan, Sue Yee, Subramaniam, Sharrada, Fan, Yong, Loh, Eva, Chang, Kenneth Tou En, Tan, Thiam Chye, Chen, Qingfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism Cell Movement Chemokine CXCL12 - metabolism Circadian Rhythm - physiology Humans Jet Lag Syndrome - physiopathology Leukocytes - physiology Mice Models, Biological p38 Mitogen-Activated Protein Kinases - metabolism Reactive Oxygen Species - metabolism Receptors, CXCR4 - metabolism
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