Diagnostic dilemma between medication-related osteonecrosis and oral squamous cell carcinoma in a mandibular lytic lesion
Osteolytic lesions of the mandible are common, and there are two important differential diagnoses that must be considered: medication-related osteonecrosis of the jaws (MRONJ) and squamous cell carcinoma (SCC). In patients with a history of taking antiresorptive medication as well as risk factors fo...
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| Veröffentlicht in: | British journal of oral & maxillofacial surgery 2017-11, Vol.55 (9), p.e53-e57 |
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| container_title | British journal of oral & maxillofacial surgery |
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| creator | Tocaciu, S. Breik, O. Lim, B. Angel, C. Rutherford, N. |
| description | Osteolytic lesions of the mandible are common, and there are two important differential diagnoses that must be considered: medication-related osteonecrosis of the jaws (MRONJ) and squamous cell carcinoma (SCC). In patients with a history of taking antiresorptive medication as well as risk factors for neoplasia it can be difficult to differentiate between the two. We describe two cases in both of which a mandibular osteolytic lesion was inadequately identified as either MRONJ or SCC because of confusing clinical and histopathological features. We also reviewed relevant publications to identify similar cases. Here we discuss our clinical dilemma when faced with two different conditions that present with similar clinical and histopathological features. |
| doi_str_mv | 10.1016/j.bjoms.2017.08.005 |
| format | Article |
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In patients with a history of taking antiresorptive medication as well as risk factors for neoplasia it can be difficult to differentiate between the two. We describe two cases in both of which a mandibular osteolytic lesion was inadequately identified as either MRONJ or SCC because of confusing clinical and histopathological features. We also reviewed relevant publications to identify similar cases. Here we discuss our clinical dilemma when faced with two different conditions that present with similar clinical and histopathological features.</description><identifier>ISSN: 0266-4356</identifier><identifier>EISSN: 1532-1940</identifier><identifier>DOI: 10.1016/j.bjoms.2017.08.005</identifier><identifier>PMID: 28851496</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Aged, 80 and over ; Biopsy ; Bisphosphonate related osteonecrosis of the jaws (BRONJ) ; Bisphosphonate-Associated Osteonecrosis of the Jaw - diagnosis ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Contrast Media ; Dentistry ; Diagnosis, Differential ; Disease Progression ; Female ; Humans ; Male ; Mandibular Neoplasms - diagnosis ; Mandibular Neoplasms - pathology ; Mandibular Neoplasms - surgery ; Medication-related osteonecrosis of the jaws (MRONJ) ; Osteonecrosis ; Radiography, Panoramic ; Risk Factors ; squamous cell carcinoma (SCC) ; Tomography, X-Ray Computed</subject><ispartof>British journal of oral & maxillofacial surgery, 2017-11, Vol.55 (9), p.e53-e57</ispartof><rights>2017 The British Association of Oral and Maxillofacial Surgeons</rights><rights>Copyright © 2017 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-73d7ca1e21e2cfd0e0c38f64164a675488ad67230b84169084e2d7b542eef4f33</citedby><cites>FETCH-LOGICAL-c385t-73d7ca1e21e2cfd0e0c38f64164a675488ad67230b84169084e2d7b542eef4f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bjoms.2017.08.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28851496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tocaciu, S.</creatorcontrib><creatorcontrib>Breik, O.</creatorcontrib><creatorcontrib>Lim, B.</creatorcontrib><creatorcontrib>Angel, C.</creatorcontrib><creatorcontrib>Rutherford, N.</creatorcontrib><title>Diagnostic dilemma between medication-related osteonecrosis and oral squamous cell carcinoma in a mandibular lytic lesion</title><title>British journal of oral & maxillofacial surgery</title><addtitle>Br J Oral Maxillofac Surg</addtitle><description>Osteolytic lesions of the mandible are common, and there are two important differential diagnoses that must be considered: medication-related osteonecrosis of the jaws (MRONJ) and squamous cell carcinoma (SCC). In patients with a history of taking antiresorptive medication as well as risk factors for neoplasia it can be difficult to differentiate between the two. We describe two cases in both of which a mandibular osteolytic lesion was inadequately identified as either MRONJ or SCC because of confusing clinical and histopathological features. We also reviewed relevant publications to identify similar cases. Here we discuss our clinical dilemma when faced with two different conditions that present with similar clinical and histopathological features.</description><subject>Aged, 80 and over</subject><subject>Biopsy</subject><subject>Bisphosphonate related osteonecrosis of the jaws (BRONJ)</subject><subject>Bisphosphonate-Associated Osteonecrosis of the Jaw - diagnosis</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Contrast Media</subject><subject>Dentistry</subject><subject>Diagnosis, Differential</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mandibular Neoplasms - diagnosis</subject><subject>Mandibular Neoplasms - pathology</subject><subject>Mandibular Neoplasms - surgery</subject><subject>Medication-related osteonecrosis of the jaws (MRONJ)</subject><subject>Osteonecrosis</subject><subject>Radiography, Panoramic</subject><subject>Risk Factors</subject><subject>squamous cell carcinoma (SCC)</subject><subject>Tomography, X-Ray Computed</subject><issn>0266-4356</issn><issn>1532-1940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE-L1jAQh4O4uK-rn0CQHL205l_T9OBBVleFBS_rOaTpVPKSJrtJq7zf3qnvrkchEBie-c3MQ8gbzlrOuH5_bMdjXmorGO9bZlrGumfkwDspGj4o9pwcmNC6UbLTl-RlrUeGhODdC3IpjOm4GvSBnD4F9zPlugZPpxBhWRwdYf0NkOgCU_BuDTk1BaJbYaIIQk7gS66hUpewUlyk9WFzS94q9RAj9a74kDImhUQdXRAL4xZdofG0z4lQMfMVuZhdrPD68b8iP24-311_bW6_f_l2_fG28dJ0a9PLqfeOg8Dn54kBw_qsFdfK6b5TxrhJ90Ky0WBtYEaBmPqxUwJgVrOUV-TdOfe-5IcN6mqXUPc9XQJc2fJBykGJwQyIyjO631cLzPa-hMWVk-XM7s7t0f51bnfnlhmLRrHr7eOAbURl_3qeJCPw4QwAnvkrQLHVB0ge9Rbwq51y-O-AP8Aple4</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Tocaciu, S.</creator><creator>Breik, O.</creator><creator>Lim, B.</creator><creator>Angel, C.</creator><creator>Rutherford, N.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20171101</creationdate><title>Diagnostic dilemma between medication-related osteonecrosis and oral squamous cell carcinoma in a mandibular lytic lesion</title><author>Tocaciu, S. ; Breik, O. ; Lim, B. ; Angel, C. ; Rutherford, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-73d7ca1e21e2cfd0e0c38f64164a675488ad67230b84169084e2d7b542eef4f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged, 80 and over</topic><topic>Biopsy</topic><topic>Bisphosphonate related osteonecrosis of the jaws (BRONJ)</topic><topic>Bisphosphonate-Associated Osteonecrosis of the Jaw - diagnosis</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Contrast Media</topic><topic>Dentistry</topic><topic>Diagnosis, Differential</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mandibular Neoplasms - diagnosis</topic><topic>Mandibular Neoplasms - pathology</topic><topic>Mandibular Neoplasms - surgery</topic><topic>Medication-related osteonecrosis of the jaws (MRONJ)</topic><topic>Osteonecrosis</topic><topic>Radiography, Panoramic</topic><topic>Risk Factors</topic><topic>squamous cell carcinoma (SCC)</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tocaciu, S.</creatorcontrib><creatorcontrib>Breik, O.</creatorcontrib><creatorcontrib>Lim, B.</creatorcontrib><creatorcontrib>Angel, C.</creatorcontrib><creatorcontrib>Rutherford, N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of oral & maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tocaciu, S.</au><au>Breik, O.</au><au>Lim, B.</au><au>Angel, C.</au><au>Rutherford, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic dilemma between medication-related osteonecrosis and oral squamous cell carcinoma in a mandibular lytic lesion</atitle><jtitle>British journal of oral & maxillofacial surgery</jtitle><addtitle>Br J Oral Maxillofac Surg</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>55</volume><issue>9</issue><spage>e53</spage><epage>e57</epage><pages>e53-e57</pages><issn>0266-4356</issn><eissn>1532-1940</eissn><abstract>Osteolytic lesions of the mandible are common, and there are two important differential diagnoses that must be considered: medication-related osteonecrosis of the jaws (MRONJ) and squamous cell carcinoma (SCC). In patients with a history of taking antiresorptive medication as well as risk factors for neoplasia it can be difficult to differentiate between the two. We describe two cases in both of which a mandibular osteolytic lesion was inadequately identified as either MRONJ or SCC because of confusing clinical and histopathological features. We also reviewed relevant publications to identify similar cases. Here we discuss our clinical dilemma when faced with two different conditions that present with similar clinical and histopathological features.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>28851496</pmid><doi>10.1016/j.bjoms.2017.08.005</doi></addata></record> |
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| identifier | ISSN: 0266-4356 |
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| subjects | Aged, 80 and over Biopsy Bisphosphonate related osteonecrosis of the jaws (BRONJ) Bisphosphonate-Associated Osteonecrosis of the Jaw - diagnosis Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Contrast Media Dentistry Diagnosis, Differential Disease Progression Female Humans Male Mandibular Neoplasms - diagnosis Mandibular Neoplasms - pathology Mandibular Neoplasms - surgery Medication-related osteonecrosis of the jaws (MRONJ) Osteonecrosis Radiography, Panoramic Risk Factors squamous cell carcinoma (SCC) Tomography, X-Ray Computed |
| title | Diagnostic dilemma between medication-related osteonecrosis and oral squamous cell carcinoma in a mandibular lytic lesion |
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