Uterine intravascular lymphoma as a cause of fever of unknown origin
Primary intravascular large B cell lymphoma (IVL) remains a diagnostic challenge because of non-specific clinical, laboratory and imaging findings. The aim of the study was to analyse the major characteristics of IVL with uterine involvement. We retrospectively collected features of IVL with uterine...
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| Veröffentlicht in: | Annals of hematology 2017-11, Vol.96 (11), p.1891-1896 |
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| creator | Hadjadj, Jérôme Nielly, Hubert Piekarski, Eve Cuccuini, Wendy Deau-Fischer, Bénedicte Hourseau, Muriel Benali, Khadija Fieschi, Claire Aletti, Marc Papo, Thomas Oksenhendler, Eric Galicier, Lionel Boutboul, David |
| description | Primary intravascular large B cell lymphoma (IVL) remains a diagnostic challenge because of non-specific clinical, laboratory and imaging findings. The aim of the study was to analyse the major characteristics of IVL with uterine involvement. We retrospectively collected features of IVL with uterine involvement that was proven histologically or demonstrated by significant
18
FDG uptake on
18
FDG-PET/CT. Findings were compared to a comprehensive literature review. Five patients were identified. All of them were admitted for fever of unknown origin (FUO), with haemophagocytic lymphohistiocytosis in three cases. None had gynaecological symptom, contrasting with the literature data. Structural imaging (including whole-body CT scan and pelvic RMI) failed to yield any diagnosis.
18
FDG-PET/CT showed intense uterine uptake in all cases. Endometrial biopsy was performed in three cases and was positive in one. Diagnosis was obtained from coelioscopic iliac adenopathy biopsy in one case and from total hysterectomy in another. Punch biopsy of skin lesions led to diagnosis in the two remaining cases. Bone marrow biopsy was normal in all cases. Clinicians should be aware of potential isolated uterine involvement in IVL, especially in elderly women with FUO. Normal structural imaging does not rule out the diagnosis and
18
FDG-TEP/CT should be performed to guide high-yielding biopsy. |
| doi_str_mv | 10.1007/s00277-017-3117-4 |
| format | Article |
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18
FDG uptake on
18
FDG-PET/CT. Findings were compared to a comprehensive literature review. Five patients were identified. All of them were admitted for fever of unknown origin (FUO), with haemophagocytic lymphohistiocytosis in three cases. None had gynaecological symptom, contrasting with the literature data. Structural imaging (including whole-body CT scan and pelvic RMI) failed to yield any diagnosis.
18
FDG-PET/CT showed intense uterine uptake in all cases. Endometrial biopsy was performed in three cases and was positive in one. Diagnosis was obtained from coelioscopic iliac adenopathy biopsy in one case and from total hysterectomy in another. Punch biopsy of skin lesions led to diagnosis in the two remaining cases. Bone marrow biopsy was normal in all cases. Clinicians should be aware of potential isolated uterine involvement in IVL, especially in elderly women with FUO. Normal structural imaging does not rule out the diagnosis and
18
FDG-TEP/CT should be performed to guide high-yielding biopsy.</description><identifier>ISSN: 0939-5555</identifier><identifier>EISSN: 1432-0584</identifier><identifier>DOI: 10.1007/s00277-017-3117-4</identifier><identifier>PMID: 28852831</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Biopsy ; Female ; Fever of Unknown Origin - diagnostic imaging ; Fever of Unknown Origin - etiology ; Fluorodeoxyglucose F18 ; Hematology ; Humans ; Lymphoma ; Lymphoma, Large B-Cell, Diffuse - complications ; Lymphoma, Large B-Cell, Diffuse - diagnostic imaging ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Article ; Positron Emission Tomography Computed Tomography - methods ; Retrospective Studies ; Uterine Neoplasms - complications ; Uterine Neoplasms - diagnostic imaging ; Vascular Neoplasms - complications ; Vascular Neoplasms - diagnostic imaging</subject><ispartof>Annals of hematology, 2017-11, Vol.96 (11), p.1891-1896</ispartof><rights>Springer-Verlag GmbH Germany 2017</rights><rights>Annals of Hematology is a copyright of Springer, 2017.</rights><rights>Springer-Verlag GmbH Germany 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-bf3f29288e5f31d324016a0c350dae99dcf145412126dfecbadb01f085b9a2723</citedby><cites>FETCH-LOGICAL-c400t-bf3f29288e5f31d324016a0c350dae99dcf145412126dfecbadb01f085b9a2723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00277-017-3117-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00277-017-3117-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28852831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hadjadj, Jérôme</creatorcontrib><creatorcontrib>Nielly, Hubert</creatorcontrib><creatorcontrib>Piekarski, Eve</creatorcontrib><creatorcontrib>Cuccuini, Wendy</creatorcontrib><creatorcontrib>Deau-Fischer, Bénedicte</creatorcontrib><creatorcontrib>Hourseau, Muriel</creatorcontrib><creatorcontrib>Benali, Khadija</creatorcontrib><creatorcontrib>Fieschi, Claire</creatorcontrib><creatorcontrib>Aletti, Marc</creatorcontrib><creatorcontrib>Papo, Thomas</creatorcontrib><creatorcontrib>Oksenhendler, Eric</creatorcontrib><creatorcontrib>Galicier, Lionel</creatorcontrib><creatorcontrib>Boutboul, David</creatorcontrib><title>Uterine intravascular lymphoma as a cause of fever of unknown origin</title><title>Annals of hematology</title><addtitle>Ann Hematol</addtitle><addtitle>Ann Hematol</addtitle><description>Primary intravascular large B cell lymphoma (IVL) remains a diagnostic challenge because of non-specific clinical, laboratory and imaging findings. The aim of the study was to analyse the major characteristics of IVL with uterine involvement. We retrospectively collected features of IVL with uterine involvement that was proven histologically or demonstrated by significant
18
FDG uptake on
18
FDG-PET/CT. Findings were compared to a comprehensive literature review. Five patients were identified. All of them were admitted for fever of unknown origin (FUO), with haemophagocytic lymphohistiocytosis in three cases. None had gynaecological symptom, contrasting with the literature data. Structural imaging (including whole-body CT scan and pelvic RMI) failed to yield any diagnosis.
18
FDG-PET/CT showed intense uterine uptake in all cases. Endometrial biopsy was performed in three cases and was positive in one. Diagnosis was obtained from coelioscopic iliac adenopathy biopsy in one case and from total hysterectomy in another. Punch biopsy of skin lesions led to diagnosis in the two remaining cases. Bone marrow biopsy was normal in all cases. Clinicians should be aware of potential isolated uterine involvement in IVL, especially in elderly women with FUO. Normal structural imaging does not rule out the diagnosis and
18
FDG-TEP/CT should be performed to guide high-yielding biopsy.</description><subject>Aged</subject><subject>Biopsy</subject><subject>Female</subject><subject>Fever of Unknown Origin - diagnostic imaging</subject><subject>Fever of Unknown Origin - etiology</subject><subject>Fluorodeoxyglucose F18</subject><subject>Hematology</subject><subject>Humans</subject><subject>Lymphoma</subject><subject>Lymphoma, Large B-Cell, Diffuse - complications</subject><subject>Lymphoma, Large B-Cell, Diffuse - diagnostic imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Positron Emission Tomography Computed Tomography - methods</subject><subject>Retrospective Studies</subject><subject>Uterine Neoplasms - complications</subject><subject>Uterine Neoplasms - diagnostic imaging</subject><subject>Vascular Neoplasms - complications</subject><subject>Vascular Neoplasms - diagnostic imaging</subject><issn>0939-5555</issn><issn>1432-0584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1LAzEQhoMotlZ_gBdZ8OJldSbJfuQofkPBiz2H7G5St-5ma9Kt9N-bslVE0DlkBvLM-4a8hJwiXCJAduUBaJbFgFnMMBx8j4yRMxpDkvN9MgbBRJyEGpEj7xcASHNOD8mI5nlCc4ZjcjtbaVdbHdV25dRa-bJvlIuaTbt87VoVKR-pqFS911FnIqPX2m2H3r7Z7sNGnavntT0mB0Y1Xp_s-oTM7u9ebh7j6fPD0831NC45wCouDDNUBG-dGIYVoxwwVVCyBCqlhahKgzzhSJGmldFloaoC0ECeFELRjLIJuRh0l65777Vfybb2pW4aZXXXe4mCMRGsRBrQ81_oouudDa-TNBU84wxT-I9CkaDAPGVZoHCgStd577SRS1e3ym0kgtwGIYcgZAhCboOQPOyc7ZT7otXV98bXzweADoAPV3au3Q_rP1U_ASKKkPU</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Hadjadj, Jérôme</creator><creator>Nielly, Hubert</creator><creator>Piekarski, Eve</creator><creator>Cuccuini, Wendy</creator><creator>Deau-Fischer, Bénedicte</creator><creator>Hourseau, Muriel</creator><creator>Benali, Khadija</creator><creator>Fieschi, Claire</creator><creator>Aletti, Marc</creator><creator>Papo, Thomas</creator><creator>Oksenhendler, Eric</creator><creator>Galicier, Lionel</creator><creator>Boutboul, David</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20171101</creationdate><title>Uterine intravascular lymphoma as a cause of fever of unknown origin</title><author>Hadjadj, Jérôme ; 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The aim of the study was to analyse the major characteristics of IVL with uterine involvement. We retrospectively collected features of IVL with uterine involvement that was proven histologically or demonstrated by significant
18
FDG uptake on
18
FDG-PET/CT. Findings were compared to a comprehensive literature review. Five patients were identified. All of them were admitted for fever of unknown origin (FUO), with haemophagocytic lymphohistiocytosis in three cases. None had gynaecological symptom, contrasting with the literature data. Structural imaging (including whole-body CT scan and pelvic RMI) failed to yield any diagnosis.
18
FDG-PET/CT showed intense uterine uptake in all cases. Endometrial biopsy was performed in three cases and was positive in one. Diagnosis was obtained from coelioscopic iliac adenopathy biopsy in one case and from total hysterectomy in another. Punch biopsy of skin lesions led to diagnosis in the two remaining cases. Bone marrow biopsy was normal in all cases. Clinicians should be aware of potential isolated uterine involvement in IVL, especially in elderly women with FUO. Normal structural imaging does not rule out the diagnosis and
18
FDG-TEP/CT should be performed to guide high-yielding biopsy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28852831</pmid><doi>10.1007/s00277-017-3117-4</doi><tpages>6</tpages></addata></record> |
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| ispartof | Annals of hematology, 2017-11, Vol.96 (11), p.1891-1896 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Biopsy Female Fever of Unknown Origin - diagnostic imaging Fever of Unknown Origin - etiology Fluorodeoxyglucose F18 Hematology Humans Lymphoma Lymphoma, Large B-Cell, Diffuse - complications Lymphoma, Large B-Cell, Diffuse - diagnostic imaging Medicine Medicine & Public Health Middle Aged Oncology Original Article Positron Emission Tomography Computed Tomography - methods Retrospective Studies Uterine Neoplasms - complications Uterine Neoplasms - diagnostic imaging Vascular Neoplasms - complications Vascular Neoplasms - diagnostic imaging |
| title | Uterine intravascular lymphoma as a cause of fever of unknown origin |
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