RanBPM: a potential therapeutic target for modulating diverse physiological disorders
•The diverse biological functions of RanBPM and its interacting partners are reviewed.•RanBPM is linked to various proteins and cellular pathways leading to modulation of numerous physiological disorders.•RanBPM can be a potential therapeutic target for dreadful diseases. The Ran-binding protein mic...
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| Veröffentlicht in: | Drug discovery today 2017-12, Vol.22 (12), p.1816-1824 |
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| container_issue | 12 |
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| container_title | Drug discovery today |
| container_volume | 22 |
| creator | Das, Soumyadip Suresh, Bharathi Kim, Hyongbum (Henry) Ramakrishna, Suresh |
| description | •The diverse biological functions of RanBPM and its interacting partners are reviewed.•RanBPM is linked to various proteins and cellular pathways leading to modulation of numerous physiological disorders.•RanBPM can be a potential therapeutic target for dreadful diseases.
The Ran-binding protein microtubule-organizing center (RanBPM) is a highly conserved nucleocytoplasmic protein involved in a variety of intracellular signaling pathways that control diverse cellular functions. RanBPM interacts with proteins that are linked to various diseases, including Alzheimer’s disease (AD), schizophrenia (SCZ), and cancer. In this article, we define the characteristics of the scaffolding protein RanBPM and focus on its interaction partners in diverse physiological disorders, such as neurological diseases, fertility disorders, and cancer. |
| doi_str_mv | 10.1016/j.drudis.2017.08.005 |
| format | Article |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - metabolism Animals Brain Diseases - metabolism Cytoskeletal Proteins - chemistry Cytoskeletal Proteins - metabolism Humans Neoplasms - metabolism Nuclear Proteins - chemistry Nuclear Proteins - metabolism Reproduction - physiology |
| title | RanBPM: a potential therapeutic target for modulating diverse physiological disorders |
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