Exosomes Derived from Mesenchymal Stem Cells Rescue Myocardial Ischaemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy Via AMPK and Akt Pathways

Background/Aims: Reperfusion after an ischaemic insult might cause infarct extension. Mesenchymal stem cell (MSC)-derived exosomes could attenuate myocardial remodelling in animal models of myocardial ischaemia reperfusion injury (MIRI), and the present study aimed to explore the related mechanisms....

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2017-01, Vol.43 (1), p.52-68
Hauptverfasser:	Liu, Liang, Jin, Xian, Hu, Cui-Fen, Li, Rong, Zhou, Zhong’e, Shen, Cheng-Xing
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Angiogenesis Animals Apoptosis - drug effects Autophagy Autophagy - drug effects Bone marrow Bone Marrow Cells - cytology Cardiomyocytes Care and treatment Cell Survival - drug effects Cells, Cultured Disease Models, Animal Exosomes Exosomes - physiology Experiments Health aspects Heart - diagnostic imaging Heart attacks Heart cells Hydrogen Peroxide - toxicity Hypoxia Ischemia Kinases Laboratory animals Male Mesenchymal stem cell Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Myocardial ischaemia/reperfusion Injury Myocardial ischemia Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Original Paper Penicillin Protein kinases Proteins Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Rodents Signal Transduction - drug effects Stem cells
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