ESCRT genes and regulation of developmental signaling
ESCRT (Endosomal Sorting Complex Required for Transport) proteins have been shown to control an increasing number of membrane-associated processes. Some of these, and prominently regulation of receptor trafficking, profoundly shape signal transduction. Evidence in fungi, plants and multiple animal m...
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| Veröffentlicht in: | Seminars in cell & developmental biology 2018-02, Vol.74, p.29-39 |
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| container_title | Seminars in cell & developmental biology |
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| creator | Horner, David S. Pasini, Maria E. Beltrame, Monica Mastrodonato, Valeria Morelli, Elena Vaccari, Thomas |
| description | ESCRT (Endosomal Sorting Complex Required for Transport) proteins have been shown to control an increasing number of membrane-associated processes. Some of these, and prominently regulation of receptor trafficking, profoundly shape signal transduction. Evidence in fungi, plants and multiple animal models support the emerging concept that ESCRTs are main actors in coordination of signaling with the changes in cells and tissues occurring during development and homeostasis. Consistent with their pleiotropic function, ESCRTs are regulated in multiple ways to tailor signaling to developmental and homeostatic needs. ESCRT activity is crucial to correct execution of developmental programs, especially at key transitions, allowing eukaryotes to thrive and preventing appearance of congenital defects. |
| doi_str_mv | 10.1016/j.semcdb.2017.08.038 |
| format | Article |
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| ispartof | Seminars in cell & developmental biology, 2018-02, Vol.74, p.29-39 |
| issn | 1084-9521 1096-3634 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Development Endocytosis Endosome ESCRT Human disease Notch Signaling Vps genes |
| title | ESCRT genes and regulation of developmental signaling |
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