Cardiovascular risk stratification in axial spondyloarthritis: carotid ultrasound is more sensitive than coronary artery calcification score to detect high-cardiovascular risk axial spondyloarthritis patients
To determine the ability of Coronary Artery Calcification Score (CACS) and carotid ultrasonography (US) to detect high cardiovascular (CV) risk axial spondyloarthritis (ax-SpA) patients. CACS and carotid plaques were assessed in 66 consecutive ax-SpA patients (51 fulfilling criteria for ankylosing s...
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| Veröffentlicht in: | Clinical and experimental rheumatology 2018-01, Vol.36 (1), p.73-80 |
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| creator | Rueda-Gotor, Javier Llorca, Javier Corrales, Alfonso Parra, José A Portilla, Virginia Genre, Fernanda Blanco, Ricardo Agudo, Mario Fuentevilla, Patricia Expósito, Rosa Mata, Cristina Pina, Trinitario González-Juanatey, Carlos González-Gay, Miguel A |
| description | To determine the ability of Coronary Artery Calcification Score (CACS) and carotid ultrasonography (US) to detect high cardiovascular (CV) risk axial spondyloarthritis (ax-SpA) patients.
CACS and carotid plaques were assessed in 66 consecutive ax-SpA patients (51 fulfilling criteria for ankylosing spondylitis and 15 for non-radiological ax-SpA) without history of CV events. The Systematic Coronary Risk Evaluation (SCORE) calculated using total cholesterol (TC-SCORE) was assessed in 64 patients without diabetes mellitus or chronic kidney disease.
The mean age of the patients and the median disease duration since the onset of symptoms were 49.3 and 14.5 years. HLA-B27 was positive in 47 (75%) patients. CV risk was categorised according to the TC-SCORE as low ( |
| format | Article |
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CACS and carotid plaques were assessed in 66 consecutive ax-SpA patients (51 fulfilling criteria for ankylosing spondylitis and 15 for non-radiological ax-SpA) without history of CV events. The Systematic Coronary Risk Evaluation (SCORE) calculated using total cholesterol (TC-SCORE) was assessed in 64 patients without diabetes mellitus or chronic kidney disease.
The mean age of the patients and the median disease duration since the onset of symptoms were 49.3 and 14.5 years. HLA-B27 was positive in 47 (75%) patients. CV risk was categorised according to the TC-SCORE as low (<1%; n=33), moderate (≥1% and<5%; n=30) and high/very high risk (≥5%; n=1). Most patients with low TC-SCORE (27/33; 82%) had normal CACS (zero), and only 1/33 had CACS >100. However, carotid plaques were observed in patients with CACS=0 (12/37; 32%) and CACS 1-100 (10/16; 62%). The sensitivity to detect high/very high CV risk using only the TC-SCORE was very low as the algorithm only detected 1/33 (3%) of patients with high/very high CV risk. Ten of 33 (30%) high/very high CV risk patients were identified using a chart TC-SCORE risk ≥5% plus the presence of CACS ≥100 in patients with moderate TC-SCORE. The replacement of CACS with carotid US identified a higher number of high/very high CV risk patients (22/33; 67%).
Carotid US is more sensitive than CACS for the detection of high CV risk in ax-SpA patients.</description><identifier>ISSN: 0392-856X</identifier><identifier>PMID: 28850022</identifier><language>eng</language><publisher>Italy</publisher><subject>Adult ; Asymptomatic Diseases ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - etiology ; Carotid Intima-Media Thickness ; Computed Tomography Angiography ; Coronary Angiography - methods ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - etiology ; Female ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Reproducibility of Results ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Spondylitis, Ankylosing - complications ; Spondylitis, Ankylosing - diagnosis ; Vascular Calcification - diagnostic imaging ; Vascular Calcification - etiology</subject><ispartof>Clinical and experimental rheumatology, 2018-01, Vol.36 (1), p.73-80</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28850022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rueda-Gotor, Javier</creatorcontrib><creatorcontrib>Llorca, Javier</creatorcontrib><creatorcontrib>Corrales, Alfonso</creatorcontrib><creatorcontrib>Parra, José A</creatorcontrib><creatorcontrib>Portilla, Virginia</creatorcontrib><creatorcontrib>Genre, Fernanda</creatorcontrib><creatorcontrib>Blanco, Ricardo</creatorcontrib><creatorcontrib>Agudo, Mario</creatorcontrib><creatorcontrib>Fuentevilla, Patricia</creatorcontrib><creatorcontrib>Expósito, Rosa</creatorcontrib><creatorcontrib>Mata, Cristina</creatorcontrib><creatorcontrib>Pina, Trinitario</creatorcontrib><creatorcontrib>González-Juanatey, Carlos</creatorcontrib><creatorcontrib>González-Gay, Miguel A</creatorcontrib><title>Cardiovascular risk stratification in axial spondyloarthritis: carotid ultrasound is more sensitive than coronary artery calcification score to detect high-cardiovascular risk axial spondyloarthritis patients</title><title>Clinical and experimental rheumatology</title><addtitle>Clin Exp Rheumatol</addtitle><description>To determine the ability of Coronary Artery Calcification Score (CACS) and carotid ultrasonography (US) to detect high cardiovascular (CV) risk axial spondyloarthritis (ax-SpA) patients.
CACS and carotid plaques were assessed in 66 consecutive ax-SpA patients (51 fulfilling criteria for ankylosing spondylitis and 15 for non-radiological ax-SpA) without history of CV events. The Systematic Coronary Risk Evaluation (SCORE) calculated using total cholesterol (TC-SCORE) was assessed in 64 patients without diabetes mellitus or chronic kidney disease.
The mean age of the patients and the median disease duration since the onset of symptoms were 49.3 and 14.5 years. HLA-B27 was positive in 47 (75%) patients. CV risk was categorised according to the TC-SCORE as low (<1%; n=33), moderate (≥1% and<5%; n=30) and high/very high risk (≥5%; n=1). Most patients with low TC-SCORE (27/33; 82%) had normal CACS (zero), and only 1/33 had CACS >100. However, carotid plaques were observed in patients with CACS=0 (12/37; 32%) and CACS 1-100 (10/16; 62%). The sensitivity to detect high/very high CV risk using only the TC-SCORE was very low as the algorithm only detected 1/33 (3%) of patients with high/very high CV risk. Ten of 33 (30%) high/very high CV risk patients were identified using a chart TC-SCORE risk ≥5% plus the presence of CACS ≥100 in patients with moderate TC-SCORE. The replacement of CACS with carotid US identified a higher number of high/very high CV risk patients (22/33; 67%).
Carotid US is more sensitive than CACS for the detection of high CV risk in ax-SpA patients.</description><subject>Adult</subject><subject>Asymptomatic Diseases</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid Artery Diseases - etiology</subject><subject>Carotid Intima-Media Thickness</subject><subject>Computed Tomography Angiography</subject><subject>Coronary Angiography - methods</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multidetector Computed Tomography</subject><subject>Plaque, Atherosclerotic</subject><subject>Predictive Value of Tests</subject><subject>Reproducibility of Results</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Spondylitis, Ankylosing - complications</subject><subject>Spondylitis, Ankylosing - diagnosis</subject><subject>Vascular Calcification - diagnostic imaging</subject><subject>Vascular Calcification - etiology</subject><issn>0392-856X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UctOwzAQzAFES-EXkI9cIjl2nAc3VPGSKnEBiVvk2lticOzgdSr6l3wSRhRxgcuOVpqZHc0eZHPKW5Y3onqaZceIL5SySlT1UTZjTSPSxubZx1IGbfxWopqsDCQYfCUYg4xmY1Sa3hHjiHw30hIcvdM762WIfTDR4AVRMvhoNJls0qCfnCYGyeADEASHibQFEnvpiPLBOxl2JKkhgZJW_d5A9SWJnmiIoCLpzXOfqz-y_ZOEjMkHXMST7HAjLcLpHhfZ4_XVw_I2X93f3C0vV_nIiiLmQFsNtRCigbputOCsKcuCrytGW6o3WrCCcVavFYAEzTkwrhivFKNS0bIEvsjOv33H4N8mwNgNBhVYKx34Cbui5Vy0vORtop7tqdN6AN2NwQypiO7nC_wTd8-K3Q</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Rueda-Gotor, Javier</creator><creator>Llorca, Javier</creator><creator>Corrales, Alfonso</creator><creator>Parra, José A</creator><creator>Portilla, Virginia</creator><creator>Genre, Fernanda</creator><creator>Blanco, Ricardo</creator><creator>Agudo, Mario</creator><creator>Fuentevilla, Patricia</creator><creator>Expósito, Rosa</creator><creator>Mata, Cristina</creator><creator>Pina, Trinitario</creator><creator>González-Juanatey, Carlos</creator><creator>González-Gay, Miguel A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201801</creationdate><title>Cardiovascular risk stratification in axial spondyloarthritis: carotid ultrasound is more sensitive than coronary artery calcification score to detect high-cardiovascular risk axial spondyloarthritis patients</title><author>Rueda-Gotor, Javier ; Llorca, Javier ; Corrales, Alfonso ; Parra, José A ; Portilla, Virginia ; Genre, Fernanda ; Blanco, Ricardo ; Agudo, Mario ; Fuentevilla, Patricia ; Expósito, Rosa ; Mata, Cristina ; Pina, Trinitario ; González-Juanatey, Carlos ; González-Gay, Miguel A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-e09de75558e778d53284413b62090dfd5212327bceeaed33e23c236c20ac044e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Asymptomatic Diseases</topic><topic>Carotid Artery Diseases - diagnostic imaging</topic><topic>Carotid Artery Diseases - etiology</topic><topic>Carotid Intima-Media Thickness</topic><topic>Computed Tomography Angiography</topic><topic>Coronary Angiography - methods</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multidetector Computed Tomography</topic><topic>Plaque, Atherosclerotic</topic><topic>Predictive Value of Tests</topic><topic>Reproducibility of Results</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Spondylitis, Ankylosing - complications</topic><topic>Spondylitis, Ankylosing - diagnosis</topic><topic>Vascular Calcification - diagnostic imaging</topic><topic>Vascular Calcification - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rueda-Gotor, Javier</creatorcontrib><creatorcontrib>Llorca, Javier</creatorcontrib><creatorcontrib>Corrales, Alfonso</creatorcontrib><creatorcontrib>Parra, José A</creatorcontrib><creatorcontrib>Portilla, Virginia</creatorcontrib><creatorcontrib>Genre, Fernanda</creatorcontrib><creatorcontrib>Blanco, Ricardo</creatorcontrib><creatorcontrib>Agudo, Mario</creatorcontrib><creatorcontrib>Fuentevilla, Patricia</creatorcontrib><creatorcontrib>Expósito, Rosa</creatorcontrib><creatorcontrib>Mata, Cristina</creatorcontrib><creatorcontrib>Pina, Trinitario</creatorcontrib><creatorcontrib>González-Juanatey, Carlos</creatorcontrib><creatorcontrib>González-Gay, Miguel A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rueda-Gotor, Javier</au><au>Llorca, Javier</au><au>Corrales, Alfonso</au><au>Parra, José A</au><au>Portilla, Virginia</au><au>Genre, Fernanda</au><au>Blanco, Ricardo</au><au>Agudo, Mario</au><au>Fuentevilla, Patricia</au><au>Expósito, Rosa</au><au>Mata, Cristina</au><au>Pina, Trinitario</au><au>González-Juanatey, Carlos</au><au>González-Gay, Miguel A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular risk stratification in axial spondyloarthritis: carotid ultrasound is more sensitive than coronary artery calcification score to detect high-cardiovascular risk axial spondyloarthritis patients</atitle><jtitle>Clinical and experimental rheumatology</jtitle><addtitle>Clin Exp Rheumatol</addtitle><date>2018-01</date><risdate>2018</risdate><volume>36</volume><issue>1</issue><spage>73</spage><epage>80</epage><pages>73-80</pages><issn>0392-856X</issn><abstract>To determine the ability of Coronary Artery Calcification Score (CACS) and carotid ultrasonography (US) to detect high cardiovascular (CV) risk axial spondyloarthritis (ax-SpA) patients.
CACS and carotid plaques were assessed in 66 consecutive ax-SpA patients (51 fulfilling criteria for ankylosing spondylitis and 15 for non-radiological ax-SpA) without history of CV events. The Systematic Coronary Risk Evaluation (SCORE) calculated using total cholesterol (TC-SCORE) was assessed in 64 patients without diabetes mellitus or chronic kidney disease.
The mean age of the patients and the median disease duration since the onset of symptoms were 49.3 and 14.5 years. HLA-B27 was positive in 47 (75%) patients. CV risk was categorised according to the TC-SCORE as low (<1%; n=33), moderate (≥1% and<5%; n=30) and high/very high risk (≥5%; n=1). Most patients with low TC-SCORE (27/33; 82%) had normal CACS (zero), and only 1/33 had CACS >100. However, carotid plaques were observed in patients with CACS=0 (12/37; 32%) and CACS 1-100 (10/16; 62%). The sensitivity to detect high/very high CV risk using only the TC-SCORE was very low as the algorithm only detected 1/33 (3%) of patients with high/very high CV risk. Ten of 33 (30%) high/very high CV risk patients were identified using a chart TC-SCORE risk ≥5% plus the presence of CACS ≥100 in patients with moderate TC-SCORE. The replacement of CACS with carotid US identified a higher number of high/very high CV risk patients (22/33; 67%).
Carotid US is more sensitive than CACS for the detection of high CV risk in ax-SpA patients.</abstract><cop>Italy</cop><pmid>28850022</pmid><tpages>8</tpages></addata></record> |
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| subjects | Adult Asymptomatic Diseases Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - etiology Carotid Intima-Media Thickness Computed Tomography Angiography Coronary Angiography - methods Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - etiology Female Humans Male Middle Aged Multidetector Computed Tomography Plaque, Atherosclerotic Predictive Value of Tests Reproducibility of Results Risk Assessment Risk Factors Severity of Illness Index Spondylitis, Ankylosing - complications Spondylitis, Ankylosing - diagnosis Vascular Calcification - diagnostic imaging Vascular Calcification - etiology |
| title | Cardiovascular risk stratification in axial spondyloarthritis: carotid ultrasound is more sensitive than coronary artery calcification score to detect high-cardiovascular risk axial spondyloarthritis patients |
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