Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists

Novel dihydroquinoxalinone acetamides containing bicyclic aminotetralins or chromans were found to be potent Bradykinin B1 receptor antagonists. Replacement of the core β-amino acid in our previously reported piperidine acetic acid and β-phenylalanine-based Bradykinin B1 antagonists by dihydroquinox...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-08, Vol.18 (16), p.4477-4481
Hauptverfasser:	Chen, Jian Jeffrey, Qian, Wenyuan, Biswas, Kaustav, Viswanadhan, Vellarkad N., Askew, Benny C., Hitchcock, Stephen, Hungate, Randall W., Arik, Leyla, Johnson, Eileen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - chemical synthesis Acetamides - chemistry Acetic Acid - chemistry Amines Biological and medical sciences Bradykinin B1 Bradykinin B1 Receptor Antagonists Chemistry, Pharmaceutical - methods Dihydroquinoxalinone acetamides Drug Design Humans Inflammation Inhibitory Concentration 50 Ligands Medical sciences Models, Chemical Molecular Conformation Molecular Structure Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pain Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Protein Binding Quinoxalines - chemical synthesis Quinoxalines - pharmacology Receptor antagonist Receptor, Bradykinin B1 - chemistry Structure-Activity Relationship Sulfonamides
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