Mutational analysis using Sanger and next generation sequencing in sporadic spindle cell hemangiomas: A study of 19 cases

Spindle cell hemangioma (SCH) is a distinct vascular soft‐tissue lesion characterized by cavernous blood vessels and a spindle cell component mainly occurring in the distal extremities of young adults. The majority of cases harbor heterozygous mutations in IDH1/2 sporadically or rarely in associatio...

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Veröffentlicht in:	Genes chromosomes & cancer 2017-12, Vol.56 (12), p.855-860
Hauptverfasser:	ten Broek, Roel W., Bekers, Elise M., de Leng, Wendy W. J., Strengman, Eric, Tops, Bastiaan B. J., Kutzner, Heinz, Leeuwis, Jan Willem, van Gorp, Joost M., Creytens, David H., Mentzel, Thomas, van Diest, Paul J., Eijkelenboom, Astrid, Flucke, Uta
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Blood vessels Child Deoxyribonucleic acid DNA DNA probes Extremities Female Hemangioma Hemangioma - genetics Hemangioma - pathology Humans Isocitrate Dehydrogenase - genetics Lesions Male Middle Aged Mosaicism Mutation Mutation hot spots Soft Tissue Neoplasms - genetics Soft Tissue Neoplasms - pathology Young adults
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