Lipase-catalyzed asymmetric synthesis of naphtho[2,3-c]furan-1(3H)-one derivatives by a one-pot dynamic kinetic resolution/intramolecular Diels–Alder reaction: Total synthesis of (−)-himbacine

[Display omitted] One-pot sequential reactions using the acyl moieties installed by enzymatic dynamic kinetic resolution of alcohols have been little investigated. In this work, the acryloyl moiety installed via the lipase/oxovanadium combo-catalyzed dynamic kinetic resolution of a racemic dienol [4...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2018-04, Vol.26 (7), p.1378-1386
Hauptverfasser:	Sugiyama, Koji, Kawanishi, Shinji, Oki, Yasuhiro, Kamiya, Marin, Hanada, Ryosuke, Egi, Masahiro, Akai, Shuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Allylic alcohol Asymmetric total synthesis Dynamic kinetic resolution Himbacine Intramolecular Diels–Alder reaction Lipase Naphthofuranone One-pot reaction
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