Nitric oxide is involved in the memory facilitation induced by spermidine in rats
Spermidine (SPD) is an endogenous polyamine that modulates N-methyl-D: -aspartate receptor functions, which has been reported to facilitate memory formation. In the current study, we investigated the involvement of nitric oxide in the facilitatory effect of SPD on the memory of adult male Wistar rat...
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| Veröffentlicht in: | Psychopharmacologia 2006-06, Vol.186 (2), p.150-158 |
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| creator | PETRI GUERRA, Gustavo FERNANDO MELLO, Carlos DUTRA SAUZEM, Patricia BOLZAN BERLESE, Daiane FLAVIA FURIAN, Ana TABARELLI, Zuleica ANTONELLO RUBIN, Maribel |
| description | Spermidine (SPD) is an endogenous polyamine that modulates N-methyl-D: -aspartate receptor functions, which has been reported to facilitate memory formation.
In the current study, we investigated the involvement of nitric oxide in the facilitatory effect of SPD on the memory of adult male Wistar rats in the inhibitory avoidance task.
The coadministration of the nonspecific NOS inhibitor N (G) nitro-L: -arginine methyl ester (L: -NAME) (0.1 nmol, intrahippocampus) with spermidine (0.2 nmol), immediately after training, prevented the memory improvement caused by spermidine in the avoidance inhibitory task. Spermidine increased nitrite and nitrate levels (NO(X)) in the hippocampus 30 min after its administration, and L: -NAME coinjection prevented the stimulatory effect of spermidine on NO(X) levels. The systemic injection of 7-nitroindazole (30 mg/kg, i.p.), 30 min before training, impaired memory and did not prevent spermidine-induced increase of NO(X) levels in the hippocampus.
These results suggest that memory enhancement by spermidine is prevented by the nonspecific nitric oxide synthase inhibitor L: -NAME. |
| doi_str_mv | 10.1007/s00213-006-0376-5 |
| format | Article |
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In the current study, we investigated the involvement of nitric oxide in the facilitatory effect of SPD on the memory of adult male Wistar rats in the inhibitory avoidance task.
The coadministration of the nonspecific NOS inhibitor N (G) nitro-L: -arginine methyl ester (L: -NAME) (0.1 nmol, intrahippocampus) with spermidine (0.2 nmol), immediately after training, prevented the memory improvement caused by spermidine in the avoidance inhibitory task. Spermidine increased nitrite and nitrate levels (NO(X)) in the hippocampus 30 min after its administration, and L: -NAME coinjection prevented the stimulatory effect of spermidine on NO(X) levels. The systemic injection of 7-nitroindazole (30 mg/kg, i.p.), 30 min before training, impaired memory and did not prevent spermidine-induced increase of NO(X) levels in the hippocampus.
These results suggest that memory enhancement by spermidine is prevented by the nonspecific nitric oxide synthase inhibitor L: -NAME.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-006-0376-5</identifier><identifier>PMID: 16601997</identifier><identifier>CODEN: PSYPAG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Avoidance Learning - drug effects ; Avoidance Learning - physiology ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Enzyme Inhibitors - pharmacology ; Hippocampus - drug effects ; Hippocampus - enzymology ; Hippocampus - metabolism ; Indazoles - pharmacology ; Male ; Medical sciences ; Memory ; Memory - drug effects ; Memory - physiology ; NG-Nitroarginine Methyl Ester - pharmacology ; Nitrates - metabolism ; Nitric oxide ; Nitric Oxide - antagonists & inhibitors ; Nitric Oxide - physiology ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitrites - metabolism ; Polyamines ; Rats ; Rats, Wistar ; Spermidine - pharmacology</subject><ispartof>Psychopharmacologia, 2006-06, Vol.186 (2), p.150-158</ispartof><rights>2006 INIST-CNRS</rights><rights>Springer-Verlag 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-f3bd4b6250785363e0cb3160b423224ab77ce653a3724811717f371a74572e073</citedby><cites>FETCH-LOGICAL-c387t-f3bd4b6250785363e0cb3160b423224ab77ce653a3724811717f371a74572e073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17785994$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16601997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PETRI GUERRA, Gustavo</creatorcontrib><creatorcontrib>FERNANDO MELLO, Carlos</creatorcontrib><creatorcontrib>DUTRA SAUZEM, Patricia</creatorcontrib><creatorcontrib>BOLZAN BERLESE, Daiane</creatorcontrib><creatorcontrib>FLAVIA FURIAN, Ana</creatorcontrib><creatorcontrib>TABARELLI, Zuleica</creatorcontrib><creatorcontrib>ANTONELLO RUBIN, Maribel</creatorcontrib><title>Nitric oxide is involved in the memory facilitation induced by spermidine in rats</title><title>Psychopharmacologia</title><addtitle>Psychopharmacology (Berl)</addtitle><description>Spermidine (SPD) is an endogenous polyamine that modulates N-methyl-D: -aspartate receptor functions, which has been reported to facilitate memory formation.
In the current study, we investigated the involvement of nitric oxide in the facilitatory effect of SPD on the memory of adult male Wistar rats in the inhibitory avoidance task.
The coadministration of the nonspecific NOS inhibitor N (G) nitro-L: -arginine methyl ester (L: -NAME) (0.1 nmol, intrahippocampus) with spermidine (0.2 nmol), immediately after training, prevented the memory improvement caused by spermidine in the avoidance inhibitory task. Spermidine increased nitrite and nitrate levels (NO(X)) in the hippocampus 30 min after its administration, and L: -NAME coinjection prevented the stimulatory effect of spermidine on NO(X) levels. The systemic injection of 7-nitroindazole (30 mg/kg, i.p.), 30 min before training, impaired memory and did not prevent spermidine-induced increase of NO(X) levels in the hippocampus.
These results suggest that memory enhancement by spermidine is prevented by the nonspecific nitric oxide synthase inhibitor L: -NAME.</description><subject>Animals</subject><subject>Avoidance Learning - drug effects</subject><subject>Avoidance Learning - physiology</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavior, Animal - physiology</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - enzymology</subject><subject>Hippocampus - metabolism</subject><subject>Indazoles - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Memory - drug effects</subject><subject>Memory - physiology</subject><subject>NG-Nitroarginine Methyl Ester - pharmacology</subject><subject>Nitrates - metabolism</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - antagonists & inhibitors</subject><subject>Nitric Oxide - physiology</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitrites - metabolism</subject><subject>Polyamines</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Spermidine - pharmacology</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkF1LwzAUQIMobk5_gC9SBH2r3uSmSfsowy8YiqDPIU1TzOjHTNrh_r0ZGwzMSwI595AcQi4p3FEAeR8AGMUUQKSAUqTZEZlSjixlINkxmQIgpkizfELOQlhCXDznp2RChQBaFHJKPt7c4J1J-l9X2cSFxHXrvlnbKh6S4dsmrW17v0lqbVzjBj24votX1WgiUm6SsLK-dZXr7HbA6yGck5NaN8Fe7PcZ-Xp6_Jy_pIv359f5wyI1mMshrbGseClYBjLPUKAFUyIVUHKGjHFdSmmsyFCjZDynVFJZo6Ra8kwyCxJn5HbnXfn-Z7RhUK0LxjaN7mw_BkULjKJomJHrf-CyH30X36YYzQsheJZHiO4g4_sQvK3VyrtW-42ioLax1S62irHVNrbaiq_24rFsbXWY2NeNwM0e0MHopva6My4cOBm_XhQc_wBe6oTQ</recordid><startdate>20060601</startdate><enddate>20060601</enddate><creator>PETRI GUERRA, Gustavo</creator><creator>FERNANDO MELLO, Carlos</creator><creator>DUTRA SAUZEM, Patricia</creator><creator>BOLZAN BERLESE, Daiane</creator><creator>FLAVIA FURIAN, Ana</creator><creator>TABARELLI, Zuleica</creator><creator>ANTONELLO RUBIN, Maribel</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20060601</creationdate><title>Nitric oxide is involved in the memory facilitation induced by spermidine in rats</title><author>PETRI GUERRA, Gustavo ; FERNANDO MELLO, Carlos ; DUTRA SAUZEM, Patricia ; BOLZAN BERLESE, Daiane ; FLAVIA FURIAN, Ana ; TABARELLI, Zuleica ; ANTONELLO RUBIN, Maribel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-f3bd4b6250785363e0cb3160b423224ab77ce653a3724811717f371a74572e073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Avoidance Learning - 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pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PETRI GUERRA, Gustavo</creatorcontrib><creatorcontrib>FERNANDO MELLO, Carlos</creatorcontrib><creatorcontrib>DUTRA SAUZEM, Patricia</creatorcontrib><creatorcontrib>BOLZAN BERLESE, Daiane</creatorcontrib><creatorcontrib>FLAVIA FURIAN, Ana</creatorcontrib><creatorcontrib>TABARELLI, Zuleica</creatorcontrib><creatorcontrib>ANTONELLO RUBIN, Maribel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Psychopharmacologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PETRI GUERRA, Gustavo</au><au>FERNANDO MELLO, Carlos</au><au>DUTRA SAUZEM, Patricia</au><au>BOLZAN BERLESE, Daiane</au><au>FLAVIA FURIAN, Ana</au><au>TABARELLI, Zuleica</au><au>ANTONELLO RUBIN, Maribel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nitric oxide is involved in the memory facilitation induced by spermidine in rats</atitle><jtitle>Psychopharmacologia</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2006-06-01</date><risdate>2006</risdate><volume>186</volume><issue>2</issue><spage>150</spage><epage>158</epage><pages>150-158</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><coden>PSYPAG</coden><abstract>Spermidine (SPD) is an endogenous polyamine that modulates N-methyl-D: -aspartate receptor functions, which has been reported to facilitate memory formation.
In the current study, we investigated the involvement of nitric oxide in the facilitatory effect of SPD on the memory of adult male Wistar rats in the inhibitory avoidance task.
The coadministration of the nonspecific NOS inhibitor N (G) nitro-L: -arginine methyl ester (L: -NAME) (0.1 nmol, intrahippocampus) with spermidine (0.2 nmol), immediately after training, prevented the memory improvement caused by spermidine in the avoidance inhibitory task. Spermidine increased nitrite and nitrate levels (NO(X)) in the hippocampus 30 min after its administration, and L: -NAME coinjection prevented the stimulatory effect of spermidine on NO(X) levels. The systemic injection of 7-nitroindazole (30 mg/kg, i.p.), 30 min before training, impaired memory and did not prevent spermidine-induced increase of NO(X) levels in the hippocampus.
These results suggest that memory enhancement by spermidine is prevented by the nonspecific nitric oxide synthase inhibitor L: -NAME.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>16601997</pmid><doi>10.1007/s00213-006-0376-5</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Avoidance Learning - drug effects Avoidance Learning - physiology Behavior, Animal - drug effects Behavior, Animal - physiology Biological and medical sciences Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Hippocampus - drug effects Hippocampus - enzymology Hippocampus - metabolism Indazoles - pharmacology Male Medical sciences Memory Memory - drug effects Memory - physiology NG-Nitroarginine Methyl Ester - pharmacology Nitrates - metabolism Nitric oxide Nitric Oxide - antagonists & inhibitors Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Nitrites - metabolism Polyamines Rats Rats, Wistar Spermidine - pharmacology |
| title | Nitric oxide is involved in the memory facilitation induced by spermidine in rats |
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