Transforming Growth Factor beta 1 Induces Hypoxia-inducible Factor-1 Stabilization through Selective Inhibition of PHD2 Expression

The hypoxia-inducible transcription factor-1 (HIF-1) is central to a number of pathological processes through the induction of specific genes such as vascular endothelial growth factor (VEGF). Even though HIF-1 is highly regulated by cellular oxygen levels, other elements of the inflammatory and tum...

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Veröffentlicht in:	The Journal of biological chemistry 2006-08, Vol.281 (34), p.24171-24181
Hauptverfasser:	McMahon, Stephanie, Charbonneau, Martine, Grandmont, Sebastien, Richard, Darren E, Dubois, Claire M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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