Esculentoside A exerts anti-inflammatory activity in microglial cells

Esculentoside A (EsA) is a saponin isolated from the roots of Phytolacca esculenta. This study was designed to evaluate the pharmacological effects of EsA on lipopolysaccharide (LPS)-stimulated BV2 microglia and primary microglia cells. Our results indicated that EsA pretreatment significantly decre...

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Veröffentlicht in:	International immunopharmacology 2017-10, Vol.51, p.148-157
Hauptverfasser:	Yang, Hui, Chen, Yijian, Yu, Linjie, Xu, Yun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - immunology Animals Anti-inflammatory agents Anti-Inflammatory Agents - pharmacology Apoptosis Caspase Caspase-1 Cell Line Chemical compounds Cyclooxygenase-2 Dinoprostone - metabolism Esculentoside A Humans Inflammasomes Inflammation Inflammatory diseases Interleukin 12 Interleukin 6 Kinases Lipopolysaccharides Lipopolysaccharides - immunology Microglia Microglia - drug effects Microglia - pathology Microglia cells Microglial cells Neurodegenerative Diseases - drug therapy Neurogenic Inflammation - drug therapy Neuroinflammation NF-kappa B - metabolism NF-κB p65 NF-κB protein Nitric oxide Nitric Oxide - metabolism Nitric-oxide synthase NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasome Oleanolic Acid - analogs & derivatives Oleanolic Acid - pharmacology Pharmacology Phosphorylation Phytolaccaceae - immunology Prostaglandin E2 Pyrin protein Rats Saponins - pharmacology Signal Transduction - drug effects Studies Translocation Tumor necrosis factor-α
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