Mutation of foxl2 or cyp19a1a Results in Female to Male Sex Reversal in XX Nile Tilapia

Abstract It is well accepted that Forkhead box protein L2 (Foxl2) and aromatase (Cyp19a1; the enzyme responsible for estrogen synthesis) are critical for ovarian development in vertebrates. Knockouts of Foxl2 and Cyp19a1 in goat, mouse, and zebrafish have revealed similar but not identical functions...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2017-08, Vol.158 (8), p.2634-2647
Hauptverfasser:	Zhang, Xianbo, Li, Mengru, Ma, He, Liu, Xingyong, Shi, Hongjuan, Li, Minghui, Wang, Deshou
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Aldosterone synthase Androgens - biosynthesis Animals Aromatase Aromatase - genetics Aromatase - metabolism Cell number Cichlids - genetics Cichlids - physiology Endocrinology Enzymes Estradiol - pharmacology Estrogens Female Females Fish Forkhead protein Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Functionals Gene Deletion Gene expression Gene Expression Regulation - drug effects Germ cells Gonads Hatching Male Males Mutants Mutation Oreochromis niloticus Ovaries Phenotypes Sex Sex Characteristics Sex Differentiation - genetics Sex hormones Sex reversal Tilapia Transcription Up-regulation Vertebrates Zebrafish
Online-Zugang:	Volltext
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