Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca super(2+)

The unique N-terminal regions of PDE4 cAMP-specific phosphodiesterases confer interaction with distinct signalling and scaffolding proteins. The PDE4A1 isoform is unique in being entirely membrane associated. Its N-terminal region is formed from two helices separated by a mobile hinge, where helix-2...

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Veröffentlicht in:	Journal of cell science 2006-09, Vol.119 (18), p.3799-3810
Hauptverfasser:	Huston, Elaine, Gall, Irene, Houslay, Thomas M, Houslay, Miles D
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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