Physical and Functional Interaction of Fyn Tyrosine Kinase with a Brain-enriched Rho GTPase-activating Protein TCGAP

Fyn, a member of the Src family of tyrosine kinases, is implicated in both brain development and adult brain function. In the present study, we identified a Rho GTPase-activating protein (GAP), TCGAP (Tc10/Cdc42 GTPase-activating protein), as a novel Fyn substrate. TCGAP interacted with Fyn and was...

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Veröffentlicht in:	The Journal of biological chemistry 2006-08, Vol.281 (33), p.23611-23619
Hauptverfasser:	Liu, Hui, Nakazawa, Takanobu, Tezuka, Tohru, Yamamoto, Tadashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution - genetics Animals Brain - embryology Brain - enzymology Brain - metabolism Cell Line Enzyme Activation - physiology Gene Expression Regulation, Developmental Growth Inhibitors - physiology GTPase-Activating Proteins - biosynthesis GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism GTPase-Activating Proteins - physiology Humans Nerve Growth Factor - antagonists & inhibitors Nerve Growth Factor - physiology Neurites - physiology PC12 Cells Phenylalanine - genetics Phosphorylation Proto-Oncogene Proteins c-fyn - chemistry Proto-Oncogene Proteins c-fyn - metabolism Proto-Oncogene Proteins c-fyn - physiology Rats rho GTP-Binding Proteins - metabolism Sorting Nexins Subcellular Fractions - metabolism Tyrosine - genetics
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