The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na super(+)-Ca super(2) super(+) exchanger function

Glycoside-induced cardiac inotropy has traditionally been attributed to direct Na super(+)-K super(+)-ATPase inhibition, causing increased intracellular [Na super(+)] and consequent Ca super(2+) gain via the Na super(+)-Ca super(2+) exchanger (NCX). However, recent studies suggested alternative mech...

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Veröffentlicht in:	The Journal of physiology 2006-09, Vol.575 (3), p.845-854
Hauptverfasser:	Altamirano, Julio, Li, Yanxia, DeSantiago, Jaime, Piacentino, Valentino 3rd, Houser, Steven R, Bers, Donald M
Format:	Artikel
Sprache:	eng
Schlagworte:	Mustela putorius furo
Online-Zugang:	Volltext
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