Association of baseline vitamin D level with genetic determinants and virologic response in patients with chronic hepatitis B
Aim The role of vitamin D in individuals with chronic hepatitis B (CHB) is unclear. We aimed to explore the association of baseline vitamin D level with genetic determinants and week‐104 treatment outcome in CHB patients. Methods Baseline serum 25‐hydroxycholecalciferol (25(OH)D) levels and genetic...
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| Veröffentlicht in: | Hepatology research 2018-02, Vol.48 (3), p.E213-E221 |
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| creator | Yu, Rui Tan, Deming Ning, Qin Niu, Junqi Bai, Xuefan Chen, Shijun Cheng, Jun Yu, Yanyan Wang, Hao Xu, Min Shi, Guangfeng Wan, Mobin Chen, Xinyue Tang, Hong Sheng, Jifang Dou, Xiaoguang Shi, Junping Ren, Hong Wang, Maorong Zhang, Hongfei Gao, Zhiliang Chen, Chengwei Ma, Hong Jia, Jidong Hou, Jinlin Xie, Qing Sun, Jian |
| description | Aim
The role of vitamin D in individuals with chronic hepatitis B (CHB) is unclear. We aimed to explore the association of baseline vitamin D level with genetic determinants and week‐104 treatment outcome in CHB patients.
Methods
Baseline serum 25‐hydroxycholecalciferol (25(OH)D) levels and genetic polymorphism within GC, DHCR7, and CYP2R1 were determined in stored serum of 560 patients who were enrolled into a multicenter, randomized, controlled study and completed 104 weeks of telbivudine monotherapy or telbivudine‐based optimized therapy. Virologic response was defined as hepatitis B virus DNA |
| doi_str_mv | 10.1111/hepr.12972 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1932168411</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1932168411</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4172-2352d79cca7738a2c88f5662fdfd41391595480ac8e075537aa2c0f56d6b14a63</originalsourceid><addsrcrecordid>eNp9kctKxDAUhoMo3jc-gATciDCaS9ukSx2vICii4K5k0lMn0klq0lFc-O6eOurChdkknPPl4yQ_ITucHXJcR1Po4iEXpRJLZJ1rJUZMZo_LeJa6GBUyK9bIRkrPjHHFRLZK1oTWWGVqnXwcpxSsM70LnoaGTkyC1nmgr643M-fpKW3hFVr65vopfQIPvbO0hh4ido3vEzW-RjqGNjxhK0Lqgk9A8W6HWhiQr8t2GoNHAsfFeu8SPdkiK41pE2x_75vk4fzsfnw5ur65uBofX49sxvE5QuaiVqW1RimpjbBaN3lRiKZu6ozLkudlnmlmrAam8lwqgwxDpC4mPDOF3CT7C28Xw8scUl_NXLLQtsZDmKeKl1LwQmecI7r3B30O8-hxOqTKcvg4PggPFpSNIaUITdVFNzPxveKsGkKphlCqr1AQ3v1WziczqH_RnxQQ4AvgzbXw_o-qujy7vVtIPwErnJgr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1999883416</pqid></control><display><type>article</type><title>Association of baseline vitamin D level with genetic determinants and virologic response in patients with chronic hepatitis B</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Yu, Rui ; Tan, Deming ; Ning, Qin ; Niu, Junqi ; Bai, Xuefan ; Chen, Shijun ; Cheng, Jun ; Yu, Yanyan ; Wang, Hao ; Xu, Min ; Shi, Guangfeng ; Wan, Mobin ; Chen, Xinyue ; Tang, Hong ; Sheng, Jifang ; Dou, Xiaoguang ; Shi, Junping ; Ren, Hong ; Wang, Maorong ; Zhang, Hongfei ; Gao, Zhiliang ; Chen, Chengwei ; Ma, Hong ; Jia, Jidong ; Hou, Jinlin ; Xie, Qing ; Sun, Jian</creator><creatorcontrib>Yu, Rui ; Tan, Deming ; Ning, Qin ; Niu, Junqi ; Bai, Xuefan ; Chen, Shijun ; Cheng, Jun ; Yu, Yanyan ; Wang, Hao ; Xu, Min ; Shi, Guangfeng ; Wan, Mobin ; Chen, Xinyue ; Tang, Hong ; Sheng, Jifang ; Dou, Xiaoguang ; Shi, Junping ; Ren, Hong ; Wang, Maorong ; Zhang, Hongfei ; Gao, Zhiliang ; Chen, Chengwei ; Ma, Hong ; Jia, Jidong ; Hou, Jinlin ; Xie, Qing ; Sun, Jian</creatorcontrib><description>Aim
The role of vitamin D in individuals with chronic hepatitis B (CHB) is unclear. We aimed to explore the association of baseline vitamin D level with genetic determinants and week‐104 treatment outcome in CHB patients.
Methods
Baseline serum 25‐hydroxycholecalciferol (25(OH)D) levels and genetic polymorphism within GC, DHCR7, and CYP2R1 were determined in stored serum of 560 patients who were enrolled into a multicenter, randomized, controlled study and completed 104 weeks of telbivudine monotherapy or telbivudine‐based optimized therapy. Virologic response was defined as hepatitis B virus DNA <300 copies/mL (52 IU/mL) at week 104.
Results
The mean 25(OH)D value was 29.64 ng/mL. The percentage of patients with vitamin D insufficiency (<30 ng/mL) and vitamin D deficiency (<20 ng/mL) were 55.0% and 20.9%, respectively. Gender, season, latitude, and GC rs2282679 polymorphism were independent factors of vitamin D status. Patients with sufficient vitamin D (≥30 ng/mL) achieved a higher virologic response rate than those with vitamin D insufficiency (81.7% vs. 67.2%, P < 0.001). The area under the curve of 25(OH)D to predict virologic response was 0.65 (P < 0.001; 95% confidence interval, 0.62–0.67). On multivariate analysis, 25(OH)D level was an independent predictor of virologic response, but not associated with hepatitis B envelope antigen (HBeAg) seroconversion or alanine aminotransferase (ALT) normalization.
Conclusions
Vitamin D insufficiency was highly prevalent in treatment‐naïve CHB patients in mainland China. Latitude and genetic determinants affect vitamin D status. Baseline vitamin D level can predict week‐104 virologic response, but not HBeAg seroconversion or ALT normalization.</description><identifier>ISSN: 1386-6346</identifier><identifier>EISSN: 1872-034X</identifier><identifier>DOI: 10.1111/hepr.12972</identifier><identifier>PMID: 28834607</identifier><language>eng</language><publisher>Netherlands: Wiley Subscription Services, Inc</publisher><subject>7-Dehydrocholesterol reductase ; Alanine ; Alanine transaminase ; Deoxyribonucleic acid ; DNA ; Gene polymorphism ; genetic determinants ; Hepatitis ; Hepatitis B ; Hepatitis B e antigen ; Latitude ; Multivariate analysis ; Seroconversion ; treatment response ; Vitamin D ; Vitamin deficiency</subject><ispartof>Hepatology research, 2018-02, Vol.48 (3), p.E213-E221</ispartof><rights>2017 The Japan Society of Hepatology</rights><rights>2017 The Japan Society of Hepatology.</rights><rights>2018 The Japan Society of Hepatology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4172-2352d79cca7738a2c88f5662fdfd41391595480ac8e075537aa2c0f56d6b14a63</citedby><cites>FETCH-LOGICAL-c4172-2352d79cca7738a2c88f5662fdfd41391595480ac8e075537aa2c0f56d6b14a63</cites><orcidid>0000-0001-5320-227X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhepr.12972$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhepr.12972$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28834607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Rui</creatorcontrib><creatorcontrib>Tan, Deming</creatorcontrib><creatorcontrib>Ning, Qin</creatorcontrib><creatorcontrib>Niu, Junqi</creatorcontrib><creatorcontrib>Bai, Xuefan</creatorcontrib><creatorcontrib>Chen, Shijun</creatorcontrib><creatorcontrib>Cheng, Jun</creatorcontrib><creatorcontrib>Yu, Yanyan</creatorcontrib><creatorcontrib>Wang, Hao</creatorcontrib><creatorcontrib>Xu, Min</creatorcontrib><creatorcontrib>Shi, Guangfeng</creatorcontrib><creatorcontrib>Wan, Mobin</creatorcontrib><creatorcontrib>Chen, Xinyue</creatorcontrib><creatorcontrib>Tang, Hong</creatorcontrib><creatorcontrib>Sheng, Jifang</creatorcontrib><creatorcontrib>Dou, Xiaoguang</creatorcontrib><creatorcontrib>Shi, Junping</creatorcontrib><creatorcontrib>Ren, Hong</creatorcontrib><creatorcontrib>Wang, Maorong</creatorcontrib><creatorcontrib>Zhang, Hongfei</creatorcontrib><creatorcontrib>Gao, Zhiliang</creatorcontrib><creatorcontrib>Chen, Chengwei</creatorcontrib><creatorcontrib>Ma, Hong</creatorcontrib><creatorcontrib>Jia, Jidong</creatorcontrib><creatorcontrib>Hou, Jinlin</creatorcontrib><creatorcontrib>Xie, Qing</creatorcontrib><creatorcontrib>Sun, Jian</creatorcontrib><title>Association of baseline vitamin D level with genetic determinants and virologic response in patients with chronic hepatitis B</title><title>Hepatology research</title><addtitle>Hepatol Res</addtitle><description>Aim
The role of vitamin D in individuals with chronic hepatitis B (CHB) is unclear. We aimed to explore the association of baseline vitamin D level with genetic determinants and week‐104 treatment outcome in CHB patients.
Methods
Baseline serum 25‐hydroxycholecalciferol (25(OH)D) levels and genetic polymorphism within GC, DHCR7, and CYP2R1 were determined in stored serum of 560 patients who were enrolled into a multicenter, randomized, controlled study and completed 104 weeks of telbivudine monotherapy or telbivudine‐based optimized therapy. Virologic response was defined as hepatitis B virus DNA <300 copies/mL (52 IU/mL) at week 104.
Results
The mean 25(OH)D value was 29.64 ng/mL. The percentage of patients with vitamin D insufficiency (<30 ng/mL) and vitamin D deficiency (<20 ng/mL) were 55.0% and 20.9%, respectively. Gender, season, latitude, and GC rs2282679 polymorphism were independent factors of vitamin D status. Patients with sufficient vitamin D (≥30 ng/mL) achieved a higher virologic response rate than those with vitamin D insufficiency (81.7% vs. 67.2%, P < 0.001). The area under the curve of 25(OH)D to predict virologic response was 0.65 (P < 0.001; 95% confidence interval, 0.62–0.67). On multivariate analysis, 25(OH)D level was an independent predictor of virologic response, but not associated with hepatitis B envelope antigen (HBeAg) seroconversion or alanine aminotransferase (ALT) normalization.
Conclusions
Vitamin D insufficiency was highly prevalent in treatment‐naïve CHB patients in mainland China. Latitude and genetic determinants affect vitamin D status. Baseline vitamin D level can predict week‐104 virologic response, but not HBeAg seroconversion or ALT normalization.</description><subject>7-Dehydrocholesterol reductase</subject><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Gene polymorphism</subject><subject>genetic determinants</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B e antigen</subject><subject>Latitude</subject><subject>Multivariate analysis</subject><subject>Seroconversion</subject><subject>treatment response</subject><subject>Vitamin D</subject><subject>Vitamin deficiency</subject><issn>1386-6346</issn><issn>1872-034X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kctKxDAUhoMo3jc-gATciDCaS9ukSx2vICii4K5k0lMn0klq0lFc-O6eOurChdkknPPl4yQ_ITucHXJcR1Po4iEXpRJLZJ1rJUZMZo_LeJa6GBUyK9bIRkrPjHHFRLZK1oTWWGVqnXwcpxSsM70LnoaGTkyC1nmgr643M-fpKW3hFVr65vopfQIPvbO0hh4ido3vEzW-RjqGNjxhK0Lqgk9A8W6HWhiQr8t2GoNHAsfFeu8SPdkiK41pE2x_75vk4fzsfnw5ur65uBofX49sxvE5QuaiVqW1RimpjbBaN3lRiKZu6ozLkudlnmlmrAam8lwqgwxDpC4mPDOF3CT7C28Xw8scUl_NXLLQtsZDmKeKl1LwQmecI7r3B30O8-hxOqTKcvg4PggPFpSNIaUITdVFNzPxveKsGkKphlCqr1AQ3v1WziczqH_RnxQQ4AvgzbXw_o-qujy7vVtIPwErnJgr</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Yu, Rui</creator><creator>Tan, Deming</creator><creator>Ning, Qin</creator><creator>Niu, Junqi</creator><creator>Bai, Xuefan</creator><creator>Chen, Shijun</creator><creator>Cheng, Jun</creator><creator>Yu, Yanyan</creator><creator>Wang, Hao</creator><creator>Xu, Min</creator><creator>Shi, Guangfeng</creator><creator>Wan, Mobin</creator><creator>Chen, Xinyue</creator><creator>Tang, Hong</creator><creator>Sheng, Jifang</creator><creator>Dou, Xiaoguang</creator><creator>Shi, Junping</creator><creator>Ren, Hong</creator><creator>Wang, Maorong</creator><creator>Zhang, Hongfei</creator><creator>Gao, Zhiliang</creator><creator>Chen, Chengwei</creator><creator>Ma, Hong</creator><creator>Jia, Jidong</creator><creator>Hou, Jinlin</creator><creator>Xie, Qing</creator><creator>Sun, Jian</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5320-227X</orcidid></search><sort><creationdate>201802</creationdate><title>Association of baseline vitamin D level with genetic determinants and virologic response in patients with chronic hepatitis B</title><author>Yu, Rui ; Tan, Deming ; Ning, Qin ; Niu, Junqi ; Bai, Xuefan ; Chen, Shijun ; Cheng, Jun ; Yu, Yanyan ; Wang, Hao ; Xu, Min ; Shi, Guangfeng ; Wan, Mobin ; Chen, Xinyue ; Tang, Hong ; Sheng, Jifang ; Dou, Xiaoguang ; Shi, Junping ; Ren, Hong ; Wang, Maorong ; Zhang, Hongfei ; Gao, Zhiliang ; Chen, Chengwei ; Ma, Hong ; Jia, Jidong ; Hou, Jinlin ; Xie, Qing ; Sun, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4172-2352d79cca7738a2c88f5662fdfd41391595480ac8e075537aa2c0f56d6b14a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>7-Dehydrocholesterol reductase</topic><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Gene polymorphism</topic><topic>genetic determinants</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B e antigen</topic><topic>Latitude</topic><topic>Multivariate analysis</topic><topic>Seroconversion</topic><topic>treatment response</topic><topic>Vitamin D</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Rui</creatorcontrib><creatorcontrib>Tan, Deming</creatorcontrib><creatorcontrib>Ning, Qin</creatorcontrib><creatorcontrib>Niu, Junqi</creatorcontrib><creatorcontrib>Bai, Xuefan</creatorcontrib><creatorcontrib>Chen, Shijun</creatorcontrib><creatorcontrib>Cheng, Jun</creatorcontrib><creatorcontrib>Yu, Yanyan</creatorcontrib><creatorcontrib>Wang, Hao</creatorcontrib><creatorcontrib>Xu, Min</creatorcontrib><creatorcontrib>Shi, Guangfeng</creatorcontrib><creatorcontrib>Wan, Mobin</creatorcontrib><creatorcontrib>Chen, Xinyue</creatorcontrib><creatorcontrib>Tang, Hong</creatorcontrib><creatorcontrib>Sheng, Jifang</creatorcontrib><creatorcontrib>Dou, Xiaoguang</creatorcontrib><creatorcontrib>Shi, Junping</creatorcontrib><creatorcontrib>Ren, Hong</creatorcontrib><creatorcontrib>Wang, Maorong</creatorcontrib><creatorcontrib>Zhang, Hongfei</creatorcontrib><creatorcontrib>Gao, Zhiliang</creatorcontrib><creatorcontrib>Chen, Chengwei</creatorcontrib><creatorcontrib>Ma, Hong</creatorcontrib><creatorcontrib>Jia, Jidong</creatorcontrib><creatorcontrib>Hou, Jinlin</creatorcontrib><creatorcontrib>Xie, Qing</creatorcontrib><creatorcontrib>Sun, Jian</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Rui</au><au>Tan, Deming</au><au>Ning, Qin</au><au>Niu, Junqi</au><au>Bai, Xuefan</au><au>Chen, Shijun</au><au>Cheng, Jun</au><au>Yu, Yanyan</au><au>Wang, Hao</au><au>Xu, Min</au><au>Shi, Guangfeng</au><au>Wan, Mobin</au><au>Chen, Xinyue</au><au>Tang, Hong</au><au>Sheng, Jifang</au><au>Dou, Xiaoguang</au><au>Shi, Junping</au><au>Ren, Hong</au><au>Wang, Maorong</au><au>Zhang, Hongfei</au><au>Gao, Zhiliang</au><au>Chen, Chengwei</au><au>Ma, Hong</au><au>Jia, Jidong</au><au>Hou, Jinlin</au><au>Xie, Qing</au><au>Sun, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of baseline vitamin D level with genetic determinants and virologic response in patients with chronic hepatitis B</atitle><jtitle>Hepatology research</jtitle><addtitle>Hepatol Res</addtitle><date>2018-02</date><risdate>2018</risdate><volume>48</volume><issue>3</issue><spage>E213</spage><epage>E221</epage><pages>E213-E221</pages><issn>1386-6346</issn><eissn>1872-034X</eissn><abstract>Aim
The role of vitamin D in individuals with chronic hepatitis B (CHB) is unclear. We aimed to explore the association of baseline vitamin D level with genetic determinants and week‐104 treatment outcome in CHB patients.
Methods
Baseline serum 25‐hydroxycholecalciferol (25(OH)D) levels and genetic polymorphism within GC, DHCR7, and CYP2R1 were determined in stored serum of 560 patients who were enrolled into a multicenter, randomized, controlled study and completed 104 weeks of telbivudine monotherapy or telbivudine‐based optimized therapy. Virologic response was defined as hepatitis B virus DNA <300 copies/mL (52 IU/mL) at week 104.
Results
The mean 25(OH)D value was 29.64 ng/mL. The percentage of patients with vitamin D insufficiency (<30 ng/mL) and vitamin D deficiency (<20 ng/mL) were 55.0% and 20.9%, respectively. Gender, season, latitude, and GC rs2282679 polymorphism were independent factors of vitamin D status. Patients with sufficient vitamin D (≥30 ng/mL) achieved a higher virologic response rate than those with vitamin D insufficiency (81.7% vs. 67.2%, P < 0.001). The area under the curve of 25(OH)D to predict virologic response was 0.65 (P < 0.001; 95% confidence interval, 0.62–0.67). On multivariate analysis, 25(OH)D level was an independent predictor of virologic response, but not associated with hepatitis B envelope antigen (HBeAg) seroconversion or alanine aminotransferase (ALT) normalization.
Conclusions
Vitamin D insufficiency was highly prevalent in treatment‐naïve CHB patients in mainland China. Latitude and genetic determinants affect vitamin D status. Baseline vitamin D level can predict week‐104 virologic response, but not HBeAg seroconversion or ALT normalization.</abstract><cop>Netherlands</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28834607</pmid><doi>10.1111/hepr.12972</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5320-227X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Hepatology research, 2018-02, Vol.48 (3), p.E213-E221 |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | 7-Dehydrocholesterol reductase Alanine Alanine transaminase Deoxyribonucleic acid DNA Gene polymorphism genetic determinants Hepatitis Hepatitis B Hepatitis B e antigen Latitude Multivariate analysis Seroconversion treatment response Vitamin D Vitamin deficiency |
| title | Association of baseline vitamin D level with genetic determinants and virologic response in patients with chronic hepatitis B |
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