Single Cell Phenotyping Reveals Heterogeneity Among Hematopoietic Stem Cells Following Infection

The hematopoietic stem cell (HSC) niche provides essential microenvironmental cues for the production and maintenance of HSCs within the bone marrow. During inflammation, hematopoietic dynamics are perturbed, but it is not known whether changes to the HSC–niche interaction occur as a result. We visu...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2017-11, Vol.35 (11), p.2292-2304
Hauptverfasser:	MacLean, Adam L., Smith, Maia A., Liepe, Juliane, Sim, Aaron, Khorshed, Reema, Rashidi, Narges M., Scherf, Nico, Krinner, Axel, Roeder, Ingo, Lo Celso, Cristina, Stumpf, Michael P. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone marrow Cell adhesion & migration Cell migration Cell Movement Computer applications Cues Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Heterogeneity In vivo systems biology In vivo tracking Infections Infections - genetics Life history Mathematical modeling Mice Microenvironments Models, Theoretical Mouse devices Phenotype Phenotyping Rodents Spatial analysis Statistical analysis Stem cell transplantation Stem cells Stem cell‐microenvironment interactions Trajectory analysis
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