Self‐assembled liver organoids recapitulate hepatobiliary organogenesis in vitro

Several three‐dimensional cell culture systems are currently available to create liver organoids. In gneral, these systems display better physiologic and metabolic aspects of intact liver tissue compared with two‐dimensional culture systems. However, none reliably mimic human liver development, incl...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2018-02, Vol.67 (2), p.750-761
Hauptverfasser:	Vyas, Dipen, Baptista, Pedro M., Brovold, Matthew, Moran, Emma, Gaston, Brandon, Booth, Chris, Samuel, Michael, Atala, Anthony, Soker, Shay
Format:	Artikel
Sprache:	eng
Schlagworte:	Alagille syndrome Animals Bile Bile ducts Bile Ducts - embryology Cell culture Cell Differentiation Cell Lineage Developmental disabilities Drug screening Extracellular matrix Extracellular Matrix - metabolism Ferrets Fetuses Hepatocytes Hepatology Humans Liver Liver - cytology Liver - embryology Liver diseases Morphogenesis Notch protein Organogenesis Organoids Organoids - physiology Progenitor cells Stem cells Stem Cells - cytology Tissue culture
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