Clonal characteristics of paired infiltrating and circulating B lymphocyte repertoire in patients with primary biliary cholangitis

Background PBC is a prototypical autoimmune liver disease characterized by portal lymphoplasmacyte infiltration. ALD is a prototypical environment‐driven disease, featured by mild lymphocyte infiltration. We hypothesize that B cells are more involved in the pathogenesis of PBC. By analysing the infi...

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Veröffentlicht in:	Liver international 2018-03, Vol.38 (3), p.542-552
Hauptverfasser:	Tan, Yan‐guo, Wang, Xiao‐feng, Zhang, Ming, Yan, Hui‐ping, Lin, Dong‐dong, Wang, Yu‐qi, Zhang, Hai‐ping, Yu, Xin‐qiu, Liao, Hui‐yu, Wang, Yi‐peng, Lv, Fu‐dong, Gao, Zu‐hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult B-Lymphocytes - cytology B-Lymphocytes - immunology Cholangitis clonal exchange Clone Cells Data processing Exchanging Expansion Female Genes, Immunoglobulin High-Throughput Nucleotide Sequencing Humans Ig repertoire Immunity Immunoglobulins Infiltration Liver Liver - pathology Liver Cirrhosis, Biliary - immunology Liver diseases Lymphocyte receptors Lymphocytes Lymphocytes B Male Middle Aged oligoclonal expansion Pathogenesis Patients Primary biliary cholangitis T cell receptors
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