Enhanced expression of Pafah1b1 causes over-migration of cerebral cortical neurons into the marginal zone

Mutations of PAFAH1B1 cause classical lissencephaly in humans. In addition, duplications and triplications of PAFAH1B1 are found in individuals with intellectual disability and other neurological disorders suggesting that proper brain development is highly sensitive to the PAFAH1B1 dosage. To examin...

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Veröffentlicht in:	Brain Structure and Function 2017-12, Vol.222 (9), p.4283-4291
Hauptverfasser:	Katayama, Kei-ichi, Hayashi, Kanehiro, Inoue, Seika, Sakaguchi, Kazushige, Nakajima, Kazunori
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism Animals Animals, Newborn Biomedical and Life Sciences Biomedicine Brain Cell Biology Cell Movement - physiology Cells, Cultured Cerebral cortex Cerebral Cortex - cytology Cerebral Cortex - embryology Cerebral Cortex - growth & development DNA-Binding Proteins - metabolism Electroporation Embryo, Mammalian Embryogenesis Gene Expression Regulation, Developmental - genetics Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism LIM-Homeodomain Proteins - metabolism Lissencephaly Mice Mice, Inbred ICR Mice, Transgenic Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Neurological diseases Neurology Neurons - physiology Neurosciences Nuclear Receptor Subfamily 1, Group F, Member 2 - metabolism Rodents Short Communication Transcription Factors - metabolism
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