Down‐regulation of aquaporin 5‐mediated epithelial‐mesenchymal transition and anti‐metastatic effect by natural product Cairicoside E in colorectal cancer

Epithelial‐mesenchymal transition (EMT) has emerged as an important determinant role in colorectal cancer (CRC) metastasis. It has been reported that aquaporin 5 (AQP5) is closely linked to CRC metastasis. However, the effect of AQP5 on the EMT process of CRC remains unknown. The current study showe...

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Veröffentlicht in:	Molecular carcinogenesis 2017-12, Vol.56 (12), p.2692-2705
Hauptverfasser:	Chen, Chen, Ma, Ting, Zhang, Chao, Zhang, Hao, Bai, Lijuan, Kong, Lingyi, Luo, Jianguang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aquaporin 5 Aquaporin 5 - genetics Aquaporin 5 - metabolism Aquaporins Biological Products - chemistry Biological Products - pharmacology Blotting, Western Cairicoside E Cell Line, Tumor Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Cytotoxicity Down-Regulation - drug effects Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - genetics epithelial‐mesenchymal transition Gene Expression Regulation, Neoplastic - drug effects Glycolipids - chemistry Glycolipids - pharmacology HCT116 Cells HEK293 Cells HT29 Cells Humans Ipomoea cairica Lung nodules Mesenchyme Metastases Metastasis Mice, Inbred BALB C Mice, Nude Molecular Structure Neoplasm Metastasis RNA Interference Smad2 protein Transforming growth factor-b1 tumor metastasis Xenograft Model Antitumor Assays
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