Reliable and simple spectrophotometric determination of sun protection factor: A case study using organic UV filter‐based sunscreen products
Summary Background Current in vitro SPF screening method for plant oil body (oleosome)‐based SPF products possesses significant inconsistency and low reliability in the SPF rating. Objectives The primary objective of this study was to evaluate the reliability and reproducibility of spectrophotometri...
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| Veröffentlicht in: | Journal of cosmetic dermatology 2018-06, Vol.17 (3), p.518-522 |
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| container_title | Journal of cosmetic dermatology |
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| creator | Yang, Soo In Liu, Shuanghui Brooks, Geoffrey J Lanctot, Yves Gruber, James V |
| description | Summary
Background
Current in vitro SPF screening method for plant oil body (oleosome)‐based SPF products possesses significant inconsistency and low reliability in the SPF rating.
Objectives
The primary objective of this study was to evaluate the reliability and reproducibility of spectrophotometrically determined sun protection factor (SPF) from oleosome‐based SPF products. The secondary objective was the data comparison of the spectrophotometric measurements against in vivo SPF testing to establish a reliable in vitro test method as a screening assay.
Methods
Octyl methoxycinnamate (UVB filter) and avobenzone (UVA filter) were loaded into safflower oil bodies and formulated into oil‐in‐water emulsion‐based finished products. To evaluate the reliability between in vivo and spectrophotometric test methods, samples were dispatched to a clinical laboratory, and the reported SPF values were compared with spectrophotometric test results.
Results
The observed SPF from the in vivo and spectrophotometric test results demonstrated a high correlation for SPF 30 products. Proportional correlation between the two evaluation methods was observed for SPF 15 and 50 products with slightly lesser accuracy with a smaller number of population tested in the clinical studies.
Conclusions
A reliable spectrophotometric screening method for oil body‐based SPF formulas has been developed using two broadly used organic UV sunscreen actives as a case study. The results demonstrated a high level of reproducibility and reliability compared to the US FDA‐guided in vivo SPF testing method. |
| doi_str_mv | 10.1111/jocd.12390 |
| format | Article |
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Background
Current in vitro SPF screening method for plant oil body (oleosome)‐based SPF products possesses significant inconsistency and low reliability in the SPF rating.
Objectives
The primary objective of this study was to evaluate the reliability and reproducibility of spectrophotometrically determined sun protection factor (SPF) from oleosome‐based SPF products. The secondary objective was the data comparison of the spectrophotometric measurements against in vivo SPF testing to establish a reliable in vitro test method as a screening assay.
Methods
Octyl methoxycinnamate (UVB filter) and avobenzone (UVA filter) were loaded into safflower oil bodies and formulated into oil‐in‐water emulsion‐based finished products. To evaluate the reliability between in vivo and spectrophotometric test methods, samples were dispatched to a clinical laboratory, and the reported SPF values were compared with spectrophotometric test results.
Results
The observed SPF from the in vivo and spectrophotometric test results demonstrated a high correlation for SPF 30 products. Proportional correlation between the two evaluation methods was observed for SPF 15 and 50 products with slightly lesser accuracy with a smaller number of population tested in the clinical studies.
Conclusions
A reliable spectrophotometric screening method for oil body‐based SPF formulas has been developed using two broadly used organic UV sunscreen actives as a case study. The results demonstrated a high level of reproducibility and reliability compared to the US FDA‐guided in vivo SPF testing method.</description><identifier>ISSN: 1473-2130</identifier><identifier>EISSN: 1473-2165</identifier><identifier>DOI: 10.1111/jocd.12390</identifier><identifier>PMID: 28834040</identifier><language>eng</language><publisher>England</publisher><subject>emulsions ; oil‐in‐water ; oleosomes ; sun protection ; sunscreens</subject><ispartof>Journal of cosmetic dermatology, 2018-06, Vol.17 (3), p.518-522</ispartof><rights>2017 The Authors. Published by Wiley Periodicals, Inc.</rights><rights>2017 The Authors. Journal of Cosmetic Dermatology Published by Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4310-a097765de5e37582b6894833488460e861d33265f820d88e5599786a857d34323</citedby><cites>FETCH-LOGICAL-c4310-a097765de5e37582b6894833488460e861d33265f820d88e5599786a857d34323</cites><orcidid>0000-0003-2220-1703</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjocd.12390$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjocd.12390$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28834040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Soo In</creatorcontrib><creatorcontrib>Liu, Shuanghui</creatorcontrib><creatorcontrib>Brooks, Geoffrey J</creatorcontrib><creatorcontrib>Lanctot, Yves</creatorcontrib><creatorcontrib>Gruber, James V</creatorcontrib><title>Reliable and simple spectrophotometric determination of sun protection factor: A case study using organic UV filter‐based sunscreen products</title><title>Journal of cosmetic dermatology</title><addtitle>J Cosmet Dermatol</addtitle><description>Summary
Background
Current in vitro SPF screening method for plant oil body (oleosome)‐based SPF products possesses significant inconsistency and low reliability in the SPF rating.
Objectives
The primary objective of this study was to evaluate the reliability and reproducibility of spectrophotometrically determined sun protection factor (SPF) from oleosome‐based SPF products. The secondary objective was the data comparison of the spectrophotometric measurements against in vivo SPF testing to establish a reliable in vitro test method as a screening assay.
Methods
Octyl methoxycinnamate (UVB filter) and avobenzone (UVA filter) were loaded into safflower oil bodies and formulated into oil‐in‐water emulsion‐based finished products. To evaluate the reliability between in vivo and spectrophotometric test methods, samples were dispatched to a clinical laboratory, and the reported SPF values were compared with spectrophotometric test results.
Results
The observed SPF from the in vivo and spectrophotometric test results demonstrated a high correlation for SPF 30 products. Proportional correlation between the two evaluation methods was observed for SPF 15 and 50 products with slightly lesser accuracy with a smaller number of population tested in the clinical studies.
Conclusions
A reliable spectrophotometric screening method for oil body‐based SPF formulas has been developed using two broadly used organic UV sunscreen actives as a case study. The results demonstrated a high level of reproducibility and reliability compared to the US FDA‐guided in vivo SPF testing method.</description><subject>emulsions</subject><subject>oil‐in‐water</subject><subject>oleosomes</subject><subject>sun protection</subject><subject>sunscreens</subject><issn>1473-2130</issn><issn>1473-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp9kMtKxDAUQIMoPkY3foBkKcJo0jRt6m4Y3wgDom5LJrnVDG1TkxSZnV8gfqNfYmZGZ-nd5BIO58JB6JCSUxrnbGaVPqUJK8gG2qVpzoYJzfjmemdkB-15PyOE5gXl22gnEYKlJCW76PMBaiOnNWDZauxN08XVd6CCs92rDbaB4IzCGgK4xrQyGNtiW2Hft7hzNkRy8VNJFaw7xyOspI-G0Os57r1pX7B1L7KNiqdnXJk6ar4_vqYR0guHVw5gadK9Cn4fbVWy9nDw-w7Q09Xl4_hmeD-5vh2P7ocqZZQMJSnyPOMaOLCci2SaiSIVjKVCpBkBkVHNWJLxSiRECwGcF0UuMil4rlnKEjZAxytvPPzWgw9lY7yCupYt2N6XtGCxYUZzHtGTFaqc9d5BVXbONNLNS0rKRf9y0b9c9o_w0a-3nzag1-hf8AjQFfBuapj_oyrvJuOLlfQHkZKSLw</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Yang, Soo In</creator><creator>Liu, Shuanghui</creator><creator>Brooks, Geoffrey J</creator><creator>Lanctot, Yves</creator><creator>Gruber, James V</creator><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2220-1703</orcidid></search><sort><creationdate>201806</creationdate><title>Reliable and simple spectrophotometric determination of sun protection factor: A case study using organic UV filter‐based sunscreen products</title><author>Yang, Soo In ; Liu, Shuanghui ; Brooks, Geoffrey J ; Lanctot, Yves ; Gruber, James V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4310-a097765de5e37582b6894833488460e861d33265f820d88e5599786a857d34323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>emulsions</topic><topic>oil‐in‐water</topic><topic>oleosomes</topic><topic>sun protection</topic><topic>sunscreens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Soo In</creatorcontrib><creatorcontrib>Liu, Shuanghui</creatorcontrib><creatorcontrib>Brooks, Geoffrey J</creatorcontrib><creatorcontrib>Lanctot, Yves</creatorcontrib><creatorcontrib>Gruber, James V</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cosmetic dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Soo In</au><au>Liu, Shuanghui</au><au>Brooks, Geoffrey J</au><au>Lanctot, Yves</au><au>Gruber, James V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reliable and simple spectrophotometric determination of sun protection factor: A case study using organic UV filter‐based sunscreen products</atitle><jtitle>Journal of cosmetic dermatology</jtitle><addtitle>J Cosmet Dermatol</addtitle><date>2018-06</date><risdate>2018</risdate><volume>17</volume><issue>3</issue><spage>518</spage><epage>522</epage><pages>518-522</pages><issn>1473-2130</issn><eissn>1473-2165</eissn><abstract>Summary
Background
Current in vitro SPF screening method for plant oil body (oleosome)‐based SPF products possesses significant inconsistency and low reliability in the SPF rating.
Objectives
The primary objective of this study was to evaluate the reliability and reproducibility of spectrophotometrically determined sun protection factor (SPF) from oleosome‐based SPF products. The secondary objective was the data comparison of the spectrophotometric measurements against in vivo SPF testing to establish a reliable in vitro test method as a screening assay.
Methods
Octyl methoxycinnamate (UVB filter) and avobenzone (UVA filter) were loaded into safflower oil bodies and formulated into oil‐in‐water emulsion‐based finished products. To evaluate the reliability between in vivo and spectrophotometric test methods, samples were dispatched to a clinical laboratory, and the reported SPF values were compared with spectrophotometric test results.
Results
The observed SPF from the in vivo and spectrophotometric test results demonstrated a high correlation for SPF 30 products. Proportional correlation between the two evaluation methods was observed for SPF 15 and 50 products with slightly lesser accuracy with a smaller number of population tested in the clinical studies.
Conclusions
A reliable spectrophotometric screening method for oil body‐based SPF formulas has been developed using two broadly used organic UV sunscreen actives as a case study. The results demonstrated a high level of reproducibility and reliability compared to the US FDA‐guided in vivo SPF testing method.</abstract><cop>England</cop><pmid>28834040</pmid><doi>10.1111/jocd.12390</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-2220-1703</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Access via Wiley Online Library |
| subjects | emulsions oil‐in‐water oleosomes sun protection sunscreens |
| title | Reliable and simple spectrophotometric determination of sun protection factor: A case study using organic UV filter‐based sunscreen products |
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