Metformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo

Hepatocellular carcinoma (HCC) has poor prognosis due to the advanced disease stages by the time it is diagnosed, high recurrence rates and metastasis. In the present study, we investigated the effects of metformin (a safe anti‐diabetic drug) and curcumin (a turmeric polyphenol extracted from rhizom...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular carcinogenesis 2018-01, Vol.57 (1), p.44-56
Hauptverfasser:	Zhang, Hui‐Hui, Zhang, Ying, Cheng, Yan‐Na, Gong, Fu‐Lian, Cao, Zhan‐Qi, Yu, Lu‐Gang, Guo, Xiu‐Li
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Angiogenesis Animals Antidiabetics Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis Carcinoma, Hepatocellular - blood supply Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Cell Line Cell Proliferation - drug effects Cells, Cultured Curcumin Curcumin - administration & dosage Diabetes mellitus Epidermal growth factor receptors Female Gelatinase A HCC Hep G2 Cells Hepatocellular carcinoma Hepatoma Humans Liver cancer Liver Neoplasms - blood supply Liver Neoplasms - drug therapy Liver Neoplasms - pathology Metastases Metastasis Metformin Metformin - administration & dosage Mice, Inbred BALB C Mice, Nude Mitochondria Neoplasm Metastasis Neovascularization, Pathologic - prevention & control NF-κB protein p53 Protein PTEN protein Rodents Signal Transduction - drug effects Stat3 protein TOR protein Tumor Burden - drug effects Tumor cells Vascular endothelial growth factor Vascular endothelial growth factor receptors Xenograft Model Antitumor Assays Xenografts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!