Determinants of The Grade A Embryos in Infertile Women; Zero-Inflated Regression Model
In assisted reproductive technology, it is important to choose high quality embryos for embryo transfer. The aim of the present study was to determine the grade A embryo count and factors related to it in infertile women. This historical cohort study included 996 infertile women. The main outcome wa...
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| Veröffentlicht in: | Cell journal (Yakhteh) 2017-10, Vol.19 (3), p.506-511 |
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| creator | Almasi-Hashiani, Amir Ghaheri, Azadeh Omani Samani, Reza |
| description | In assisted reproductive technology, it is important to choose high quality embryos for embryo transfer. The aim of the present study was to determine the grade A embryo count and factors related to it in infertile women.
This historical cohort study included 996 infertile women. The main outcome was the number of grade A embryos. Zero-Inflated Poisson (ZIP) regression and Zero-Inflated Negative Binomial (ZINB) regression were used to model the count data as it contained excessive zeros. Stata software, version 13 (Stata Corp, College Station, TX, USA) was used for all statistical analyses.
After adjusting for potential confounders, results from the ZINB model show that for each unit increase in the number 2 pronuclear (2PN) zygotes, we get an increase of 1.45 times as incidence rate ratio (95% confidence interval (CI): 1.23-1.69, P=0.001) in the expected grade A embryo count number, and for each increase in the cleavage day we get a decrease 0.35 times (95% CI: 0.20-0.61, P=0.001) in expected grade A embryo count.
There is a significant association between both the number of 2PN zygotes and cleavage day with the number of grade A embryos in both ZINB and ZIP regression models. The estimated coefficients are more plausible than values found in earlier studies using less relevant models. |
| doi_str_mv | 10.22074/cellj.2017.4214 |
| format | Article |
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This historical cohort study included 996 infertile women. The main outcome was the number of grade A embryos. Zero-Inflated Poisson (ZIP) regression and Zero-Inflated Negative Binomial (ZINB) regression were used to model the count data as it contained excessive zeros. Stata software, version 13 (Stata Corp, College Station, TX, USA) was used for all statistical analyses.
After adjusting for potential confounders, results from the ZINB model show that for each unit increase in the number 2 pronuclear (2PN) zygotes, we get an increase of 1.45 times as incidence rate ratio (95% confidence interval (CI): 1.23-1.69, P=0.001) in the expected grade A embryo count number, and for each increase in the cleavage day we get a decrease 0.35 times (95% CI: 0.20-0.61, P=0.001) in expected grade A embryo count.
There is a significant association between both the number of 2PN zygotes and cleavage day with the number of grade A embryos in both ZINB and ZIP regression models. The estimated coefficients are more plausible than values found in earlier studies using less relevant models.</description><identifier>ISSN: 2228-5806</identifier><identifier>EISSN: 2228-5814</identifier><identifier>DOI: 10.22074/cellj.2017.4214</identifier><identifier>PMID: 28836413</identifier><language>eng</language><publisher>Iran: Royan Institute of Iran</publisher><subject>Age ; Body mass index ; Cleavage ; Confidence intervals ; Couples ; Embryo transfer ; Embryos ; Fertility ; Genomes ; In vitro fertilization ; Infertility ; Pregnancy ; Quality ; Regression analysis ; Regression models ; Reproductive technologies ; Reproductive technology ; Sperm ; Statistical analysis ; Studies ; Variables ; Womens health ; Zygotes</subject><ispartof>Cell journal (Yakhteh), 2017-10, Vol.19 (3), p.506-511</ispartof><rights>Copyright© by Royan Institute. All rights reserved.</rights><rights>2017. This work is published under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright Dr Ali Akbari Sari, Director of The Commission for Accreditation & Improvement of Iranian Medical Journals Oct-Dec 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,861,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28836413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Almasi-Hashiani, Amir</creatorcontrib><creatorcontrib>Ghaheri, Azadeh</creatorcontrib><creatorcontrib>Omani Samani, Reza</creatorcontrib><title>Determinants of The Grade A Embryos in Infertile Women; Zero-Inflated Regression Model</title><title>Cell journal (Yakhteh)</title><addtitle>Cell J</addtitle><description>In assisted reproductive technology, it is important to choose high quality embryos for embryo transfer. The aim of the present study was to determine the grade A embryo count and factors related to it in infertile women.
This historical cohort study included 996 infertile women. The main outcome was the number of grade A embryos. Zero-Inflated Poisson (ZIP) regression and Zero-Inflated Negative Binomial (ZINB) regression were used to model the count data as it contained excessive zeros. Stata software, version 13 (Stata Corp, College Station, TX, USA) was used for all statistical analyses.
After adjusting for potential confounders, results from the ZINB model show that for each unit increase in the number 2 pronuclear (2PN) zygotes, we get an increase of 1.45 times as incidence rate ratio (95% confidence interval (CI): 1.23-1.69, P=0.001) in the expected grade A embryo count number, and for each increase in the cleavage day we get a decrease 0.35 times (95% CI: 0.20-0.61, P=0.001) in expected grade A embryo count.
There is a significant association between both the number of 2PN zygotes and cleavage day with the number of grade A embryos in both ZINB and ZIP regression models. The estimated coefficients are more plausible than values found in earlier studies using less relevant models.</description><subject>Age</subject><subject>Body mass index</subject><subject>Cleavage</subject><subject>Confidence intervals</subject><subject>Couples</subject><subject>Embryo transfer</subject><subject>Embryos</subject><subject>Fertility</subject><subject>Genomes</subject><subject>In vitro fertilization</subject><subject>Infertility</subject><subject>Pregnancy</subject><subject>Quality</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Reproductive technologies</subject><subject>Reproductive technology</subject><subject>Sperm</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Variables</subject><subject>Womens health</subject><subject>Zygotes</subject><issn>2228-5806</issn><issn>2228-5814</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0EtLw0AQAOBFFFtq755kwYuX1H0k-8BTqbUWKoJUBS9h051oSpKtu8mh_94VHwcvzmWG4WOYGYROKZkwRmR6uYG63k4YoXKSMpoeoCFjTCWZounhb03EAI1D2JIYgjCq2TEaMKW4SCkfoqdr6MA3VWvaLmBX4vUb4IU3FvAUz5vC713AVYuXbQm-q2rAz66B9gq_gHdJ7NamA4sf4NVDCJVr8Z2zUJ-go9LUAcbfeYQeb-br2W2yul8sZ9NVsmNCdoko2aaQmVCq4Nooq9NyY6m0hhJrudCcaygoSQ3QjSxiAC2UjPdxnVlFNR-hi6-5O-_eewhd3lTh8y-mBdeHPBJGBVeERnr-h25d79u4XVSaRkfj3H8USzOtZVRn36ovGrD5zleN8fv856_8Ayy1eOI</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Almasi-Hashiani, Amir</creator><creator>Ghaheri, Azadeh</creator><creator>Omani Samani, Reza</creator><general>Royan Institute of Iran</general><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201710</creationdate><title>Determinants of The Grade A Embryos in Infertile Women; 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Zero-Inflated Regression Model</atitle><jtitle>Cell journal (Yakhteh)</jtitle><addtitle>Cell J</addtitle><date>2017-10</date><risdate>2017</risdate><volume>19</volume><issue>3</issue><spage>506</spage><epage>511</epage><pages>506-511</pages><issn>2228-5806</issn><eissn>2228-5814</eissn><abstract>In assisted reproductive technology, it is important to choose high quality embryos for embryo transfer. The aim of the present study was to determine the grade A embryo count and factors related to it in infertile women.
This historical cohort study included 996 infertile women. The main outcome was the number of grade A embryos. Zero-Inflated Poisson (ZIP) regression and Zero-Inflated Negative Binomial (ZINB) regression were used to model the count data as it contained excessive zeros. Stata software, version 13 (Stata Corp, College Station, TX, USA) was used for all statistical analyses.
After adjusting for potential confounders, results from the ZINB model show that for each unit increase in the number 2 pronuclear (2PN) zygotes, we get an increase of 1.45 times as incidence rate ratio (95% confidence interval (CI): 1.23-1.69, P=0.001) in the expected grade A embryo count number, and for each increase in the cleavage day we get a decrease 0.35 times (95% CI: 0.20-0.61, P=0.001) in expected grade A embryo count.
There is a significant association between both the number of 2PN zygotes and cleavage day with the number of grade A embryos in both ZINB and ZIP regression models. The estimated coefficients are more plausible than values found in earlier studies using less relevant models.</abstract><cop>Iran</cop><pub>Royan Institute of Iran</pub><pmid>28836413</pmid><doi>10.22074/cellj.2017.4214</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; PubMed Central |
| subjects | Age Body mass index Cleavage Confidence intervals Couples Embryo transfer Embryos Fertility Genomes In vitro fertilization Infertility Pregnancy Quality Regression analysis Regression models Reproductive technologies Reproductive technology Sperm Statistical analysis Studies Variables Womens health Zygotes |
| title | Determinants of The Grade A Embryos in Infertile Women; Zero-Inflated Regression Model |
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