Effects of natural ligands and synthetic triorganotin compounds of nuclear retinoid X receptors in human MCF-7 breast cancer cell line

Effects of natural ligands and synthetic triorganotin compounds of nuclear retinoid X receptors in human MCF-7 breast cancer cell line

In the present study, we analyzed in vitro effects of natural and synthetic triorganotin ligands of nuclear retinoid X receptors in human MCF-7 breast cancer cells. Our data has shown that all-trans retinoic acid significantly reduced expression of RXRalpha mRNA, Bcl2 and enhanced expression of BAX...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:General physiology and biophysics 2017-10, Vol.36 (4), p.481-484
Hauptverfasser: Macejova, Dana, Toporova, Lucia, Brtko, Julius
Format: Artikel
Sprache:eng
Schlagworte:
Cell Nucleus - drug effects
Cell Nucleus - metabolism
Humans
MCF-7 Cells
Organotin Compounds - administration & dosage
Retinoid X Receptors - metabolism
Tretinoin - administration & dosage
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 484
container_issue 4
container_start_page 481
container_title General physiology and biophysics
container_volume 36
creator Macejova, Dana
Toporova, Lucia
Brtko, Julius
description In the present study, we analyzed in vitro effects of natural and synthetic triorganotin ligands of nuclear retinoid X receptors in human MCF-7 breast cancer cells. Our data has shown that all-trans retinoic acid significantly reduced expression of RXRalpha mRNA, Bcl2 and enhanced expression of BAX proteins. Tributyltin bromide markedly decreased mRNA level of RXRalpha and RXRbeta. Significantly reduced levels of both RXRs proteins were observed after treatment with tributyltin chloride (TBT-Cl) but not after treatment with triphenyltin chloride (TPT-Cl) for RXRbeta protein. Both RXRalpha and RXRbeta protein levels decrease was found also by combination ATRA+TBT-Cl/TPT-Cl.
doi_str_mv 10.4149/gpb_2017038
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1932163739</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1932163739</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-9f4f0baf0ea8881373d653b729af303b485e33a964495a9b4ab843fed944bcb93</originalsourceid><addsrcrecordid>eNpNkM1KxTAQhYMoelFX7iVLQapJJm2TpVz8A8WNgruSpMm10iY1SRe-gM9ty1VxFjMD882Z4SB0QskFp1xebkbdMEJrAmIHrSiAKDiwchetCANalEKwA3Sc0juZo6wlY2QfHTAhoCoJXaGva-esyQkHh73KU1Q97ruN8m3Cc8Lp0-c3mzuDc-xCnAchdx6bMIxhWqBlbzK9VRHHmfOha_Hr3Bo75hATnuG3aVAeP65vihrraFXK2ChvbMTG9ss5b4_QnlN9ssc_9RC93Fw_r--Kh6fb-_XVQ2GAVbmQjjuilSNWCSEo1NBWJeiaSeWAgOaitABKVpzLUknNlRYcnG0l59poCYfobKs7xvAx2ZSboUvLF8rbMKWGSmC0mnUX9HyLmhhSitY1Y-wGFT8bSprF--af9zN9-iM86cG2f-yv0_ANpkCA0g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1932163739</pqid></control><display><type>article</type><title>Effects of natural ligands and synthetic triorganotin compounds of nuclear retinoid X receptors in human MCF-7 breast cancer cell line</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Macejova, Dana ; Toporova, Lucia ; Brtko, Julius</creator><creatorcontrib>Macejova, Dana ; Toporova, Lucia ; Brtko, Julius</creatorcontrib><description>In the present study, we analyzed in vitro effects of natural and synthetic triorganotin ligands of nuclear retinoid X receptors in human MCF-7 breast cancer cells. Our data has shown that all-trans retinoic acid significantly reduced expression of RXRalpha mRNA, Bcl2 and enhanced expression of BAX proteins. Tributyltin bromide markedly decreased mRNA level of RXRalpha and RXRbeta. Significantly reduced levels of both RXRs proteins were observed after treatment with tributyltin chloride (TBT-Cl) but not after treatment with triphenyltin chloride (TPT-Cl) for RXRbeta protein. Both RXRalpha and RXRbeta protein levels decrease was found also by combination ATRA+TBT-Cl/TPT-Cl.</description><identifier>ISSN: 0231-5882</identifier><identifier>ISSN: 1338-4325</identifier><identifier>EISSN: 1338-4325</identifier><identifier>DOI: 10.4149/gpb_2017038</identifier><identifier>PMID: 28836501</identifier><language>eng</language><publisher>Slovakia</publisher><subject>Cell Nucleus - drug effects ; Cell Nucleus - metabolism ; Humans ; MCF-7 Cells ; Organotin Compounds - administration &amp; dosage ; Retinoid X Receptors - metabolism ; Tretinoin - administration &amp; dosage</subject><ispartof>General physiology and biophysics, 2017-10, Vol.36 (4), p.481-484</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-9f4f0baf0ea8881373d653b729af303b485e33a964495a9b4ab843fed944bcb93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28836501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Macejova, Dana</creatorcontrib><creatorcontrib>Toporova, Lucia</creatorcontrib><creatorcontrib>Brtko, Julius</creatorcontrib><title>Effects of natural ligands and synthetic triorganotin compounds of nuclear retinoid X receptors in human MCF-7 breast cancer cell line</title><title>General physiology and biophysics</title><addtitle>Gen Physiol Biophys</addtitle><description>In the present study, we analyzed in vitro effects of natural and synthetic triorganotin ligands of nuclear retinoid X receptors in human MCF-7 breast cancer cells. Our data has shown that all-trans retinoic acid significantly reduced expression of RXRalpha mRNA, Bcl2 and enhanced expression of BAX proteins. Tributyltin bromide markedly decreased mRNA level of RXRalpha and RXRbeta. Significantly reduced levels of both RXRs proteins were observed after treatment with tributyltin chloride (TBT-Cl) but not after treatment with triphenyltin chloride (TPT-Cl) for RXRbeta protein. Both RXRalpha and RXRbeta protein levels decrease was found also by combination ATRA+TBT-Cl/TPT-Cl.</description><subject>Cell Nucleus - drug effects</subject><subject>Cell Nucleus - metabolism</subject><subject>Humans</subject><subject>MCF-7 Cells</subject><subject>Organotin Compounds - administration &amp; dosage</subject><subject>Retinoid X Receptors - metabolism</subject><subject>Tretinoin - administration &amp; dosage</subject><issn>0231-5882</issn><issn>1338-4325</issn><issn>1338-4325</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1KxTAQhYMoelFX7iVLQapJJm2TpVz8A8WNgruSpMm10iY1SRe-gM9ty1VxFjMD882Z4SB0QskFp1xebkbdMEJrAmIHrSiAKDiwchetCANalEKwA3Sc0juZo6wlY2QfHTAhoCoJXaGva-esyQkHh73KU1Q97ruN8m3Cc8Lp0-c3mzuDc-xCnAchdx6bMIxhWqBlbzK9VRHHmfOha_Hr3Bo75hATnuG3aVAeP65vihrraFXK2ChvbMTG9ss5b4_QnlN9ssc_9RC93Fw_r--Kh6fb-_XVQ2GAVbmQjjuilSNWCSEo1NBWJeiaSeWAgOaitABKVpzLUknNlRYcnG0l59poCYfobKs7xvAx2ZSboUvLF8rbMKWGSmC0mnUX9HyLmhhSitY1Y-wGFT8bSprF--af9zN9-iM86cG2f-yv0_ANpkCA0g</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Macejova, Dana</creator><creator>Toporova, Lucia</creator><creator>Brtko, Julius</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20171001</creationdate><title>Effects of natural ligands and synthetic triorganotin compounds of nuclear retinoid X receptors in human MCF-7 breast cancer cell line</title><author>Macejova, Dana ; Toporova, Lucia ; Brtko, Julius</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-9f4f0baf0ea8881373d653b729af303b485e33a964495a9b4ab843fed944bcb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Cell Nucleus - drug effects</topic><topic>Cell Nucleus - metabolism</topic><topic>Humans</topic><topic>MCF-7 Cells</topic><topic>Organotin Compounds - administration &amp; dosage</topic><topic>Retinoid X Receptors - metabolism</topic><topic>Tretinoin - administration &amp; dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Macejova, Dana</creatorcontrib><creatorcontrib>Toporova, Lucia</creatorcontrib><creatorcontrib>Brtko, Julius</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>General physiology and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Macejova, Dana</au><au>Toporova, Lucia</au><au>Brtko, Julius</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of natural ligands and synthetic triorganotin compounds of nuclear retinoid X receptors in human MCF-7 breast cancer cell line</atitle><jtitle>General physiology and biophysics</jtitle><addtitle>Gen Physiol Biophys</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>36</volume><issue>4</issue><spage>481</spage><epage>484</epage><pages>481-484</pages><issn>0231-5882</issn><issn>1338-4325</issn><eissn>1338-4325</eissn><abstract>In the present study, we analyzed in vitro effects of natural and synthetic triorganotin ligands of nuclear retinoid X receptors in human MCF-7 breast cancer cells. Our data has shown that all-trans retinoic acid significantly reduced expression of RXRalpha mRNA, Bcl2 and enhanced expression of BAX proteins. Tributyltin bromide markedly decreased mRNA level of RXRalpha and RXRbeta. Significantly reduced levels of both RXRs proteins were observed after treatment with tributyltin chloride (TBT-Cl) but not after treatment with triphenyltin chloride (TPT-Cl) for RXRbeta protein. Both RXRalpha and RXRbeta protein levels decrease was found also by combination ATRA+TBT-Cl/TPT-Cl.</abstract><cop>Slovakia</cop><pmid>28836501</pmid><doi>10.4149/gpb_2017038</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0231-5882
ispartof General physiology and biophysics, 2017-10, Vol.36 (4), p.481-484
issn 0231-5882
1338-4325
1338-4325
language eng
recordid cdi_proquest_miscellaneous_1932163739
source MEDLINE; Alma/SFX Local Collection
subjects Cell Nucleus - drug effects
Cell Nucleus - metabolism
Humans
MCF-7 Cells
Organotin Compounds - administration & dosage
Retinoid X Receptors - metabolism
Tretinoin - administration & dosage
title Effects of natural ligands and synthetic triorganotin compounds of nuclear retinoid X receptors in human MCF-7 breast cancer cell line
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T04%3A40%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20natural%20ligands%20and%20synthetic%20triorganotin%20compounds%20of%20nuclear%20retinoid%20X%20receptors%20in%20human%20MCF-7%20breast%20cancer%20cell%20line&rft.jtitle=General%20physiology%20and%20biophysics&rft.au=Macejova,%20Dana&rft.date=2017-10-01&rft.volume=36&rft.issue=4&rft.spage=481&rft.epage=484&rft.pages=481-484&rft.issn=0231-5882&rft.eissn=1338-4325&rft_id=info:doi/10.4149/gpb_2017038&rft_dat=%3Cproquest_cross%3E1932163739%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1932163739&rft_id=info:pmid/28836501&rfr_iscdi=true