Epidemiology and prognosis of candidaemia in elderly patients
Summary The aim of the study was to analyse the epidemiology and prognosis of candidaemia in elderly patients. We performed a comparison of clinical presentation of candidaemia according to age and a study of hazard factors within a prospective programme performed in 29 hospitals. One hundred and se...
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| Veröffentlicht in: | Mycoses 2017-12, Vol.60 (12), p.808-817 |
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| creator | Ramos‐Martínez, Antonio Vicente‐López, Natalia Sánchez‐Romero, Isabel Padilla, Belén Merino‐Amador, Paloma Garnacho‐Montero, José Ruiz‐Camps, Isabel Montejo, Miguel Salavert, Miguel Mensa, José Cuenca‐Estrella, Manuel Muñoz, Patricia Guinea, Jesús Paño Pardo, José Ramón García‐Rodríguez, Julio Cerrada, Carlos García Fortún, Jesús Martín, Pilar Gómez, Elia Ryan, Pablo Campelo, Carolina Santos Gil, Ignacio Buendía, Ventura Gorricho, Beatriz Perez Alonso, Mercedes Sanz, Francisca Sanz Aguado, José María Romo, Fernando González Gorgolas, Miguel Gadea, Ignacio Losa, Juan Emilio Delgado‐Iribarren, Alberto Romero, Yolanda Zaragoza, Oscar Rodriguez‐Baño, Jesús Suarez, Ana Isabel Loza, Ana Aller García, Ana Isabel Martín‐Mazuelos, Estrella Pérez de Pipaón, Maite Ruiz Ortiz, Carlos Chávez, Mónica Maroto, Fernando L. Salavert, Miguel Pemán, Javier Blanquer, José Navarro, David Camarena, Juan José Zaragoza, Rafael Abril, Vicente Gimeno, Concepción Hernáez, Silvia Ezpeleta, Guillermo Bereciartua, Elena Hernández Almaraz, José L. Montejo, Miguel Rivas, Rosa Ana Ayarza, Rafael Planes, Ana Mª Almirante, Benito Almela, Manel Gurgui, Mercè Sánchez‐Reus, Ferran Martinez‐Montauti, Joaquin Sierra, Montserrat Horcajada, Juan Pablo Sorli, Luisa Gómez, Julià Gené, Amadeu Urrea, Mireia Valerio, Maricela Díaz‐Martín, Ana Puchades, Francesc Mularoni, Alessandra |
| description | Summary
The aim of the study was to analyse the epidemiology and prognosis of candidaemia in elderly patients. We performed a comparison of clinical presentation of candidaemia according to age and a study of hazard factors within a prospective programme performed in 29 hospitals. One hundred and seventy‐six episodes occurred in elderly patients (>75 years), 227 episodes in middle‐aged patients (61‐75 years) and 232 episodes in younger patients (16‐60 years). Central venous catheter, parenteral nutrition, neutropenia, immunosuppressive therapy and candidaemia caused by Candida parapsilosis were less frequent in elderly patients. These patients received inadequate antifungal therapy (57.3%) more frequently than middle‐aged and younger patients (40.5% P < .001). Mortality during the first week (20%) and 30 days (42%) was higher in elderly patients. The variables independently associated with mortality in elderly patients during the first 7 days were acute renal failure (OR: 2.64), Pitt score (OR: 1.57) and appropriate antifungal therapy (OR: 0.132). Primary candidaemia (OR: 2.93), acute renal failure (OR: 3.68), Pitt score (OR: 1.38), appropriate antifungal therapy (OR: 0.3) and early removal of the central catheter (OR: 0.47) were independently associated with 30‐day mortality.In conclussion, inadequate antifungal treatment is frequently prescribed to elderly patients with candidaemia and is related with early and late mortality. |
| doi_str_mv | 10.1111/myc.12677 |
| format | Article |
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The aim of the study was to analyse the epidemiology and prognosis of candidaemia in elderly patients. We performed a comparison of clinical presentation of candidaemia according to age and a study of hazard factors within a prospective programme performed in 29 hospitals. One hundred and seventy‐six episodes occurred in elderly patients (>75 years), 227 episodes in middle‐aged patients (61‐75 years) and 232 episodes in younger patients (16‐60 years). Central venous catheter, parenteral nutrition, neutropenia, immunosuppressive therapy and candidaemia caused by Candida parapsilosis were less frequent in elderly patients. These patients received inadequate antifungal therapy (57.3%) more frequently than middle‐aged and younger patients (40.5% P < .001). Mortality during the first week (20%) and 30 days (42%) was higher in elderly patients. The variables independently associated with mortality in elderly patients during the first 7 days were acute renal failure (OR: 2.64), Pitt score (OR: 1.57) and appropriate antifungal therapy (OR: 0.132). Primary candidaemia (OR: 2.93), acute renal failure (OR: 3.68), Pitt score (OR: 1.38), appropriate antifungal therapy (OR: 0.3) and early removal of the central catheter (OR: 0.47) were independently associated with 30‐day mortality.In conclussion, inadequate antifungal treatment is frequently prescribed to elderly patients with candidaemia and is related with early and late mortality.</description><identifier>ISSN: 0933-7407</identifier><identifier>EISSN: 1439-0507</identifier><identifier>DOI: 10.1111/myc.12677</identifier><identifier>PMID: 28836309</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; antifungal agents ; Antifungal Agents - therapeutic use ; Candida - classification ; Candida - drug effects ; Candida - genetics ; Candida - isolation & purification ; candidaemia ; Candidemia ; Candidemia - diagnosis ; Candidemia - epidemiology ; Catheters ; central venous catheters ; Epidemiology ; Female ; Geriatrics ; Humans ; Immunosuppressive agents ; Kidneys ; Male ; Middle age ; Middle Aged ; Mortality ; Neutropenia ; Parenteral nutrition ; Prognosis ; Prospective Studies ; Renal failure ; Spain - epidemiology ; Young Adult</subject><ispartof>Mycoses, 2017-12, Vol.60 (12), p.808-817</ispartof><rights>2017 Blackwell Verlag GmbH</rights><rights>2017 Blackwell Verlag GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3537-e1217935d1f2212134e25d39845e691a1090c0cbddbd55d0de061c79249178ef3</citedby><cites>FETCH-LOGICAL-c3537-e1217935d1f2212134e25d39845e691a1090c0cbddbd55d0de061c79249178ef3</cites><orcidid>0000-0002-4840-9425</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fmyc.12677$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fmyc.12677$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28836309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramos‐Martínez, Antonio</creatorcontrib><creatorcontrib>Vicente‐López, Natalia</creatorcontrib><creatorcontrib>Sánchez‐Romero, Isabel</creatorcontrib><creatorcontrib>Padilla, Belén</creatorcontrib><creatorcontrib>Merino‐Amador, Paloma</creatorcontrib><creatorcontrib>Garnacho‐Montero, José</creatorcontrib><creatorcontrib>Ruiz‐Camps, Isabel</creatorcontrib><creatorcontrib>Montejo, Miguel</creatorcontrib><creatorcontrib>Salavert, Miguel</creatorcontrib><creatorcontrib>Mensa, José</creatorcontrib><creatorcontrib>Cuenca‐Estrella, Manuel</creatorcontrib><creatorcontrib>Muñoz, Patricia</creatorcontrib><creatorcontrib>Guinea, Jesús</creatorcontrib><creatorcontrib>Paño Pardo, José Ramón</creatorcontrib><creatorcontrib>García‐Rodríguez, Julio</creatorcontrib><creatorcontrib>Cerrada, Carlos García</creatorcontrib><creatorcontrib>Fortún, Jesús</creatorcontrib><creatorcontrib>Martín, Pilar</creatorcontrib><creatorcontrib>Gómez, Elia</creatorcontrib><creatorcontrib>Ryan, Pablo</creatorcontrib><creatorcontrib>Campelo, Carolina</creatorcontrib><creatorcontrib>Santos Gil, Ignacio</creatorcontrib><creatorcontrib>Buendía, Ventura</creatorcontrib><creatorcontrib>Gorricho, Beatriz Perez</creatorcontrib><creatorcontrib>Alonso, Mercedes</creatorcontrib><creatorcontrib>Sanz, Francisca Sanz</creatorcontrib><creatorcontrib>Aguado, José María</creatorcontrib><creatorcontrib>Romo, Fernando González</creatorcontrib><creatorcontrib>Gorgolas, Miguel</creatorcontrib><creatorcontrib>Gadea, Ignacio</creatorcontrib><creatorcontrib>Losa, Juan Emilio</creatorcontrib><creatorcontrib>Delgado‐Iribarren, Alberto</creatorcontrib><creatorcontrib>Romero, Yolanda</creatorcontrib><creatorcontrib>Zaragoza, Oscar</creatorcontrib><creatorcontrib>Rodriguez‐Baño, Jesús</creatorcontrib><creatorcontrib>Suarez, Ana Isabel</creatorcontrib><creatorcontrib>Loza, Ana</creatorcontrib><creatorcontrib>Aller García, Ana Isabel</creatorcontrib><creatorcontrib>Martín‐Mazuelos, Estrella</creatorcontrib><creatorcontrib>Pérez de Pipaón, Maite Ruiz</creatorcontrib><creatorcontrib>Ortiz, Carlos</creatorcontrib><creatorcontrib>Chávez, Mónica</creatorcontrib><creatorcontrib>Maroto, Fernando L.</creatorcontrib><creatorcontrib>Salavert, Miguel</creatorcontrib><creatorcontrib>Pemán, Javier</creatorcontrib><creatorcontrib>Blanquer, José</creatorcontrib><creatorcontrib>Navarro, David</creatorcontrib><creatorcontrib>Camarena, Juan José</creatorcontrib><creatorcontrib>Zaragoza, Rafael</creatorcontrib><creatorcontrib>Abril, Vicente</creatorcontrib><creatorcontrib>Gimeno, Concepción</creatorcontrib><creatorcontrib>Hernáez, Silvia</creatorcontrib><creatorcontrib>Ezpeleta, Guillermo</creatorcontrib><creatorcontrib>Bereciartua, Elena</creatorcontrib><creatorcontrib>Hernández Almaraz, José L.</creatorcontrib><creatorcontrib>Montejo, Miguel</creatorcontrib><creatorcontrib>Rivas, Rosa Ana</creatorcontrib><creatorcontrib>Ayarza, Rafael</creatorcontrib><creatorcontrib>Planes, Ana Mª</creatorcontrib><creatorcontrib>Almirante, Benito</creatorcontrib><creatorcontrib>Almela, Manel</creatorcontrib><creatorcontrib>Gurgui, Mercè</creatorcontrib><creatorcontrib>Sánchez‐Reus, Ferran</creatorcontrib><creatorcontrib>Martinez‐Montauti, Joaquin</creatorcontrib><creatorcontrib>Sierra, Montserrat</creatorcontrib><creatorcontrib>Horcajada, Juan Pablo</creatorcontrib><creatorcontrib>Sorli, Luisa</creatorcontrib><creatorcontrib>Gómez, Julià</creatorcontrib><creatorcontrib>Gené, Amadeu</creatorcontrib><creatorcontrib>Urrea, Mireia</creatorcontrib><creatorcontrib>Valerio, Maricela</creatorcontrib><creatorcontrib>Díaz‐Martín, Ana</creatorcontrib><creatorcontrib>Puchades, Francesc</creatorcontrib><creatorcontrib>Mularoni, Alessandra</creatorcontrib><creatorcontrib>Members of the CANDIPOP Project from GEIH-GEMICOMED (SEIMC) and REIPI</creatorcontrib><creatorcontrib>the Members of the CANDIPOP Project from GEIH‐GEMICOMED (SEIMC) and REIPI</creatorcontrib><title>Epidemiology and prognosis of candidaemia in elderly patients</title><title>Mycoses</title><addtitle>Mycoses</addtitle><description>Summary
The aim of the study was to analyse the epidemiology and prognosis of candidaemia in elderly patients. We performed a comparison of clinical presentation of candidaemia according to age and a study of hazard factors within a prospective programme performed in 29 hospitals. One hundred and seventy‐six episodes occurred in elderly patients (>75 years), 227 episodes in middle‐aged patients (61‐75 years) and 232 episodes in younger patients (16‐60 years). Central venous catheter, parenteral nutrition, neutropenia, immunosuppressive therapy and candidaemia caused by Candida parapsilosis were less frequent in elderly patients. These patients received inadequate antifungal therapy (57.3%) more frequently than middle‐aged and younger patients (40.5% P < .001). Mortality during the first week (20%) and 30 days (42%) was higher in elderly patients. The variables independently associated with mortality in elderly patients during the first 7 days were acute renal failure (OR: 2.64), Pitt score (OR: 1.57) and appropriate antifungal therapy (OR: 0.132). Primary candidaemia (OR: 2.93), acute renal failure (OR: 3.68), Pitt score (OR: 1.38), appropriate antifungal therapy (OR: 0.3) and early removal of the central catheter (OR: 0.47) were independently associated with 30‐day mortality.In conclussion, inadequate antifungal treatment is frequently prescribed to elderly patients with candidaemia and is related with early and late mortality.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>antifungal agents</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Candida - classification</subject><subject>Candida - drug effects</subject><subject>Candida - genetics</subject><subject>Candida - isolation & purification</subject><subject>candidaemia</subject><subject>Candidemia</subject><subject>Candidemia - diagnosis</subject><subject>Candidemia - epidemiology</subject><subject>Catheters</subject><subject>central venous catheters</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Immunosuppressive agents</subject><subject>Kidneys</subject><subject>Male</subject><subject>Middle age</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neutropenia</subject><subject>Parenteral nutrition</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Renal failure</subject><subject>Spain - epidemiology</subject><subject>Young Adult</subject><issn>0933-7407</issn><issn>1439-0507</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAURS0EoqUw8AdQJBYY0vojtuOBAVXlQypigYHJSu2XylUSl7gRyr_HkMKAhJdnPR3dd3UQOid4SuKb1b2ZEiqkPEBjkjGVYo7lIRpjxVgqMyxH6CSEDcZEKiqO0YjmORMMqzG6WWydhdr5yq_7pGhssm39uvHBhcSXiYkbZ4sIFIlrEqgstFWfbIudg2YXTtFRWVQBzvZzgl7vFi_zh3T5fP84v12mhnEmUyA0XmbckpLS-GcZUG6ZyjMOQpGCYIUNNitrV5Zziy1gQUzsmikicyjZBF0NubHcewdhp2sXDFRV0YDvgiaKUSKo4Diil3_Qje_aJraLlJA5kTQqmqDrgTKtD6GFUm9bVxdtrwnWX051dKq_nUb2Yp_YrWqwv-SPxAjMBuDDVdD_n6Sf3uZD5Cew334_</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Ramos‐Martínez, Antonio</creator><creator>Vicente‐López, Natalia</creator><creator>Sánchez‐Romero, Isabel</creator><creator>Padilla, Belén</creator><creator>Merino‐Amador, Paloma</creator><creator>Garnacho‐Montero, José</creator><creator>Ruiz‐Camps, Isabel</creator><creator>Montejo, Miguel</creator><creator>Salavert, Miguel</creator><creator>Mensa, José</creator><creator>Cuenca‐Estrella, Manuel</creator><creator>Muñoz, Patricia</creator><creator>Guinea, Jesús</creator><creator>Paño Pardo, José Ramón</creator><creator>García‐Rodríguez, Julio</creator><creator>Cerrada, Carlos García</creator><creator>Fortún, Jesús</creator><creator>Martín, Pilar</creator><creator>Gómez, Elia</creator><creator>Ryan, Pablo</creator><creator>Campelo, Carolina</creator><creator>Santos Gil, Ignacio</creator><creator>Buendía, Ventura</creator><creator>Gorricho, Beatriz Perez</creator><creator>Alonso, Mercedes</creator><creator>Sanz, Francisca Sanz</creator><creator>Aguado, José María</creator><creator>Romo, Fernando González</creator><creator>Gorgolas, Miguel</creator><creator>Gadea, Ignacio</creator><creator>Losa, Juan Emilio</creator><creator>Delgado‐Iribarren, Alberto</creator><creator>Romero, Yolanda</creator><creator>Zaragoza, Oscar</creator><creator>Rodriguez‐Baño, 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Mercè</creator><creator>Sánchez‐Reus, Ferran</creator><creator>Martinez‐Montauti, Joaquin</creator><creator>Sierra, Montserrat</creator><creator>Horcajada, Juan Pablo</creator><creator>Sorli, Luisa</creator><creator>Gómez, Julià</creator><creator>Gené, Amadeu</creator><creator>Urrea, Mireia</creator><creator>Valerio, Maricela</creator><creator>Díaz‐Martín, Ana</creator><creator>Puchades, Francesc</creator><creator>Mularoni, Alessandra</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4840-9425</orcidid></search><sort><creationdate>201712</creationdate><title>Epidemiology and prognosis of candidaemia in elderly patients</title><author>Ramos‐Martínez, Antonio ; Vicente‐López, Natalia ; Sánchez‐Romero, Isabel ; Padilla, Belén ; Merino‐Amador, Paloma ; Garnacho‐Montero, José ; Ruiz‐Camps, Isabel ; Montejo, Miguel ; Salavert, Miguel ; Mensa, José ; Cuenca‐Estrella, Manuel ; Muñoz, Patricia ; Guinea, Jesús ; Paño Pardo, José Ramón ; García‐Rodríguez, Julio ; Cerrada, Carlos García ; Fortún, Jesús ; Martín, Pilar ; Gómez, Elia ; Ryan, Pablo ; Campelo, Carolina ; Santos Gil, Ignacio ; Buendía, Ventura ; Gorricho, Beatriz Perez ; Alonso, Mercedes ; Sanz, Francisca Sanz ; Aguado, José María ; Romo, Fernando González ; Gorgolas, Miguel ; Gadea, Ignacio ; Losa, Juan Emilio ; Delgado‐Iribarren, Alberto ; Romero, Yolanda ; Zaragoza, Oscar ; Rodriguez‐Baño, Jesús ; Suarez, Ana Isabel ; Loza, Ana ; Aller García, Ana Isabel ; Martín‐Mazuelos, Estrella ; Pérez de Pipaón, Maite Ruiz ; Ortiz, Carlos ; Chávez, Mónica ; Maroto, Fernando L. ; Salavert, Miguel ; Pemán, Javier ; Blanquer, José ; Navarro, David ; Camarena, Juan José ; Zaragoza, Rafael ; Abril, Vicente ; Gimeno, Concepción ; Hernáez, Silvia ; Ezpeleta, Guillermo ; Bereciartua, Elena ; Hernández Almaraz, José L. ; Montejo, Miguel ; Rivas, Rosa Ana ; Ayarza, Rafael ; Planes, Ana Mª ; Almirante, Benito ; Almela, Manel ; Gurgui, Mercè ; Sánchez‐Reus, Ferran ; Martinez‐Montauti, Joaquin ; Sierra, Montserrat ; Horcajada, Juan Pablo ; Sorli, Luisa ; Gómez, Julià ; Gené, Amadeu ; Urrea, Mireia ; Valerio, Maricela ; Díaz‐Martín, Ana ; Puchades, Francesc ; Mularoni, Alessandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-e1217935d1f2212134e25d39845e691a1090c0cbddbd55d0de061c79249178ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>antifungal agents</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Candida - classification</topic><topic>Candida - drug effects</topic><topic>Candida - genetics</topic><topic>Candida - isolation & purification</topic><topic>candidaemia</topic><topic>Candidemia</topic><topic>Candidemia - diagnosis</topic><topic>Candidemia - epidemiology</topic><topic>Catheters</topic><topic>central venous catheters</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Immunosuppressive agents</topic><topic>Kidneys</topic><topic>Male</topic><topic>Middle age</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neutropenia</topic><topic>Parenteral nutrition</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Renal failure</topic><topic>Spain - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramos‐Martínez, Antonio</creatorcontrib><creatorcontrib>Vicente‐López, Natalia</creatorcontrib><creatorcontrib>Sánchez‐Romero, Isabel</creatorcontrib><creatorcontrib>Padilla, Belén</creatorcontrib><creatorcontrib>Merino‐Amador, Paloma</creatorcontrib><creatorcontrib>Garnacho‐Montero, José</creatorcontrib><creatorcontrib>Ruiz‐Camps, Isabel</creatorcontrib><creatorcontrib>Montejo, Miguel</creatorcontrib><creatorcontrib>Salavert, Miguel</creatorcontrib><creatorcontrib>Mensa, José</creatorcontrib><creatorcontrib>Cuenca‐Estrella, Manuel</creatorcontrib><creatorcontrib>Muñoz, Patricia</creatorcontrib><creatorcontrib>Guinea, Jesús</creatorcontrib><creatorcontrib>Paño Pardo, José Ramón</creatorcontrib><creatorcontrib>García‐Rodríguez, Julio</creatorcontrib><creatorcontrib>Cerrada, Carlos García</creatorcontrib><creatorcontrib>Fortún, Jesús</creatorcontrib><creatorcontrib>Martín, Pilar</creatorcontrib><creatorcontrib>Gómez, Elia</creatorcontrib><creatorcontrib>Ryan, Pablo</creatorcontrib><creatorcontrib>Campelo, Carolina</creatorcontrib><creatorcontrib>Santos Gil, Ignacio</creatorcontrib><creatorcontrib>Buendía, Ventura</creatorcontrib><creatorcontrib>Gorricho, Beatriz Perez</creatorcontrib><creatorcontrib>Alonso, Mercedes</creatorcontrib><creatorcontrib>Sanz, Francisca Sanz</creatorcontrib><creatorcontrib>Aguado, José María</creatorcontrib><creatorcontrib>Romo, Fernando González</creatorcontrib><creatorcontrib>Gorgolas, Miguel</creatorcontrib><creatorcontrib>Gadea, Ignacio</creatorcontrib><creatorcontrib>Losa, Juan Emilio</creatorcontrib><creatorcontrib>Delgado‐Iribarren, Alberto</creatorcontrib><creatorcontrib>Romero, Yolanda</creatorcontrib><creatorcontrib>Zaragoza, Oscar</creatorcontrib><creatorcontrib>Rodriguez‐Baño, Jesús</creatorcontrib><creatorcontrib>Suarez, Ana Isabel</creatorcontrib><creatorcontrib>Loza, Ana</creatorcontrib><creatorcontrib>Aller García, Ana Isabel</creatorcontrib><creatorcontrib>Martín‐Mazuelos, Estrella</creatorcontrib><creatorcontrib>Pérez de Pipaón, Maite Ruiz</creatorcontrib><creatorcontrib>Ortiz, Carlos</creatorcontrib><creatorcontrib>Chávez, Mónica</creatorcontrib><creatorcontrib>Maroto, Fernando L.</creatorcontrib><creatorcontrib>Salavert, Miguel</creatorcontrib><creatorcontrib>Pemán, Javier</creatorcontrib><creatorcontrib>Blanquer, José</creatorcontrib><creatorcontrib>Navarro, David</creatorcontrib><creatorcontrib>Camarena, Juan José</creatorcontrib><creatorcontrib>Zaragoza, Rafael</creatorcontrib><creatorcontrib>Abril, Vicente</creatorcontrib><creatorcontrib>Gimeno, Concepción</creatorcontrib><creatorcontrib>Hernáez, Silvia</creatorcontrib><creatorcontrib>Ezpeleta, Guillermo</creatorcontrib><creatorcontrib>Bereciartua, Elena</creatorcontrib><creatorcontrib>Hernández Almaraz, José L.</creatorcontrib><creatorcontrib>Montejo, Miguel</creatorcontrib><creatorcontrib>Rivas, Rosa Ana</creatorcontrib><creatorcontrib>Ayarza, Rafael</creatorcontrib><creatorcontrib>Planes, Ana Mª</creatorcontrib><creatorcontrib>Almirante, Benito</creatorcontrib><creatorcontrib>Almela, Manel</creatorcontrib><creatorcontrib>Gurgui, Mercè</creatorcontrib><creatorcontrib>Sánchez‐Reus, Ferran</creatorcontrib><creatorcontrib>Martinez‐Montauti, Joaquin</creatorcontrib><creatorcontrib>Sierra, Montserrat</creatorcontrib><creatorcontrib>Horcajada, Juan Pablo</creatorcontrib><creatorcontrib>Sorli, Luisa</creatorcontrib><creatorcontrib>Gómez, Julià</creatorcontrib><creatorcontrib>Gené, Amadeu</creatorcontrib><creatorcontrib>Urrea, Mireia</creatorcontrib><creatorcontrib>Valerio, Maricela</creatorcontrib><creatorcontrib>Díaz‐Martín, Ana</creatorcontrib><creatorcontrib>Puchades, Francesc</creatorcontrib><creatorcontrib>Mularoni, Alessandra</creatorcontrib><creatorcontrib>Members of the CANDIPOP Project from GEIH-GEMICOMED (SEIMC) and REIPI</creatorcontrib><creatorcontrib>the Members of the CANDIPOP Project from GEIH‐GEMICOMED (SEIMC) and REIPI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Mycoses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramos‐Martínez, Antonio</au><au>Vicente‐López, Natalia</au><au>Sánchez‐Romero, Isabel</au><au>Padilla, Belén</au><au>Merino‐Amador, Paloma</au><au>Garnacho‐Montero, José</au><au>Ruiz‐Camps, Isabel</au><au>Montejo, Miguel</au><au>Salavert, Miguel</au><au>Mensa, José</au><au>Cuenca‐Estrella, Manuel</au><au>Muñoz, Patricia</au><au>Guinea, Jesús</au><au>Paño Pardo, José Ramón</au><au>García‐Rodríguez, Julio</au><au>Cerrada, Carlos García</au><au>Fortún, Jesús</au><au>Martín, Pilar</au><au>Gómez, Elia</au><au>Ryan, Pablo</au><au>Campelo, Carolina</au><au>Santos Gil, Ignacio</au><au>Buendía, Ventura</au><au>Gorricho, Beatriz Perez</au><au>Alonso, Mercedes</au><au>Sanz, Francisca Sanz</au><au>Aguado, José María</au><au>Romo, Fernando González</au><au>Gorgolas, Miguel</au><au>Gadea, Ignacio</au><au>Losa, Juan Emilio</au><au>Delgado‐Iribarren, Alberto</au><au>Romero, Yolanda</au><au>Zaragoza, Oscar</au><au>Rodriguez‐Baño, Jesús</au><au>Suarez, Ana Isabel</au><au>Loza, Ana</au><au>Aller García, Ana Isabel</au><au>Martín‐Mazuelos, Estrella</au><au>Pérez de Pipaón, Maite Ruiz</au><au>Ortiz, Carlos</au><au>Chávez, Mónica</au><au>Maroto, Fernando L.</au><au>Salavert, Miguel</au><au>Pemán, Javier</au><au>Blanquer, José</au><au>Navarro, David</au><au>Camarena, Juan José</au><au>Zaragoza, Rafael</au><au>Abril, Vicente</au><au>Gimeno, Concepción</au><au>Hernáez, Silvia</au><au>Ezpeleta, Guillermo</au><au>Bereciartua, Elena</au><au>Hernández Almaraz, José L.</au><au>Montejo, Miguel</au><au>Rivas, Rosa Ana</au><au>Ayarza, Rafael</au><au>Planes, Ana Mª</au><au>Almirante, Benito</au><au>Almela, Manel</au><au>Gurgui, Mercè</au><au>Sánchez‐Reus, Ferran</au><au>Martinez‐Montauti, Joaquin</au><au>Sierra, Montserrat</au><au>Horcajada, Juan Pablo</au><au>Sorli, Luisa</au><au>Gómez, Julià</au><au>Gené, Amadeu</au><au>Urrea, Mireia</au><au>Valerio, Maricela</au><au>Díaz‐Martín, Ana</au><au>Puchades, Francesc</au><au>Mularoni, Alessandra</au><aucorp>Members of the CANDIPOP Project from GEIH-GEMICOMED (SEIMC) and REIPI</aucorp><aucorp>the Members of the CANDIPOP Project from GEIH‐GEMICOMED (SEIMC) and REIPI</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology and prognosis of candidaemia in elderly patients</atitle><jtitle>Mycoses</jtitle><addtitle>Mycoses</addtitle><date>2017-12</date><risdate>2017</risdate><volume>60</volume><issue>12</issue><spage>808</spage><epage>817</epage><pages>808-817</pages><issn>0933-7407</issn><eissn>1439-0507</eissn><abstract>Summary
The aim of the study was to analyse the epidemiology and prognosis of candidaemia in elderly patients. We performed a comparison of clinical presentation of candidaemia according to age and a study of hazard factors within a prospective programme performed in 29 hospitals. One hundred and seventy‐six episodes occurred in elderly patients (>75 years), 227 episodes in middle‐aged patients (61‐75 years) and 232 episodes in younger patients (16‐60 years). Central venous catheter, parenteral nutrition, neutropenia, immunosuppressive therapy and candidaemia caused by Candida parapsilosis were less frequent in elderly patients. These patients received inadequate antifungal therapy (57.3%) more frequently than middle‐aged and younger patients (40.5% P < .001). Mortality during the first week (20%) and 30 days (42%) was higher in elderly patients. The variables independently associated with mortality in elderly patients during the first 7 days were acute renal failure (OR: 2.64), Pitt score (OR: 1.57) and appropriate antifungal therapy (OR: 0.132). Primary candidaemia (OR: 2.93), acute renal failure (OR: 3.68), Pitt score (OR: 1.38), appropriate antifungal therapy (OR: 0.3) and early removal of the central catheter (OR: 0.47) were independently associated with 30‐day mortality.In conclussion, inadequate antifungal treatment is frequently prescribed to elderly patients with candidaemia and is related with early and late mortality.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28836309</pmid><doi>10.1111/myc.12677</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4840-9425</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0933-7407 |
| ispartof | Mycoses, 2017-12, Vol.60 (12), p.808-817 |
| issn | 0933-7407 1439-0507 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1932162650 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Aged, 80 and over antifungal agents Antifungal Agents - therapeutic use Candida - classification Candida - drug effects Candida - genetics Candida - isolation & purification candidaemia Candidemia Candidemia - diagnosis Candidemia - epidemiology Catheters central venous catheters Epidemiology Female Geriatrics Humans Immunosuppressive agents Kidneys Male Middle age Middle Aged Mortality Neutropenia Parenteral nutrition Prognosis Prospective Studies Renal failure Spain - epidemiology Young Adult |
| title | Epidemiology and prognosis of candidaemia in elderly patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T05%3A59%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Epidemiology%20and%20prognosis%20of%20candidaemia%20in%20elderly%20patients&rft.jtitle=Mycoses&rft.au=Ramos%E2%80%90Mart%C3%ADnez,%20Antonio&rft.aucorp=Members%20of%20the%20CANDIPOP%20Project%20from%20GEIH-GEMICOMED%20(SEIMC)%20and%20REIPI&rft.date=2017-12&rft.volume=60&rft.issue=12&rft.spage=808&rft.epage=817&rft.pages=808-817&rft.issn=0933-7407&rft.eissn=1439-0507&rft_id=info:doi/10.1111/myc.12677&rft_dat=%3Cproquest_cross%3E1967817214%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1967817214&rft_id=info:pmid/28836309&rfr_iscdi=true |