Detection of First-Line Drug Resistance Mutations and Drug–Protein Interaction Dynamics from Tuberculosis Patients in South India

Background: Diagnosis of drug-resistant tuberculosis predominantly relies on culture-based drug susceptibility testing, which take weeks to produce a result and a more time-efficient alternative method is multiplex allele-specific PCR (MAS-PCR). Also, understanding the role of mutations in causing r...

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Veröffentlicht in:	Microbial drug resistance (Larchmont, N.Y.) N.Y.), 2018-05, Vol.24 (4), p.377-385
Hauptverfasser:	Nachappa, Somanna Ajjamada, Neelambike, Sumana M., Amruthavalli, Chokkanna, Ramachandra, Nallur B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Antitubercular Agents - pharmacology Bacterial Proteins - genetics Binding Catalytic Domain - drug effects Catalytic Domain - genetics Deoxyribonucleic acid Disruption DNA DNA sequencing Drug interaction Drug resistance Drug Resistance, Multiple, Bacterial - drug effects Drug Resistance, Multiple, Bacterial - genetics Free energy Genetic testing Genomics Humans India Infectious diseases Isoniazid Isoniazid - pharmacology Mechanisms Microbial Sensitivity Tests - methods Molecular docking Molecular Docking Simulation - methods Multidrug resistance Multiplex Polymerase Chain Reaction - methods Mutation Mutation - drug effects Mutation - genetics Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Polymerase chain reaction Proteins Rifampin Rifampin - pharmacology RNA polymerase RpoB protein Sequence Analysis, DNA - methods Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - microbiology
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