Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

Deleted in liver cancer 1 (DLC1) is a recently identified tumor suppressor gene frequently underexpressed in hepatocellular carcinoma (HCC). DLC1 encodes a Rho GTPase-activating protein domain that exhibits growth-suppressive activity in HCC cell lines. Our recent finding has revealed that inhibitio...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-09, Vol.66 (17), p.8367-8372
Hauptverfasser:	YAM, Judy Wai Ping, KO, Frankie Chi Fat, CHAN, Chung-Yiu, JIN, Dong-Yan, NG, Irene Oi-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biological and medical sciences Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Caveolae - pathology Caveolae - physiology Cell Line Cell Line, Tumor Colony-Forming Units Assay Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Genes, Reporter Glutathione Transferase - metabolism GTPase-Activating Proteins - metabolism Humans Kidney Liver - physiology Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Microfilament Proteins - genetics Microfilament Proteins - metabolism Mutagenesis, Site-Directed Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Tensins Transfection Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors
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