Msx2 is required for vascular smooth muscle cells osteoblastic differentiation but not calcification in insulin-resistant ob/ob mice

Obesity and diabetes potentiate vascular calcification by increasing vascular smooth muscle cells osteoblastic differentiation mediated by the transcription factor Msx2 and bone morphogenetic protein-2 signaling. However, Bmp-2/Msx2 crosstalk to induce VSMC osteogenic phenotype transition and calcif...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Atherosclerosis 2017-10, Vol.265, p.14-21
Hauptverfasser:	Andrade, Maria Claudina, Carmo, Luciana S., Farias-Silva, Elisangela, Liberman, Marcel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - metabolism Aorta - pathology Aortic Diseases - genetics Aortic Diseases - metabolism Aortic Diseases - pathology Bone Morphogenetic Protein 2 - deficiency Bone Morphogenetic Protein 2 - genetics Cells, Cultured Diabetes mellitus Disease Models, Animal Genetic Predisposition to Disease Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Insulin Resistance - genetics Male Mice, Inbred C57BL Mice, Knockout Mice, Obese Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Obesity - genetics Obesity - metabolism Obesity - pathology Osteoblasts - metabolism Osteoblasts - pathology Osteogenesis Phenotype RNA Interference Signal Transduction Transfection Vascular calcification Vascular Calcification - genetics Vascular Calcification - metabolism Vascular Calcification - pathology Vascular smooth muscle cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!