Tumor Necrosis Factor-induced Long Myosin Light Chain Kinase Transcription Is Regulated by Differentiation-dependent Signaling Events: CHARACTERIZATION OF THE HUMAN LONG MYOSIN LIGHT CHAIN KINASE PROMOTER

Myosin light chain kinase (MLCK) is expressed as long and short isoforms from unique transcriptional start sites within a single gene. Tumor necrosis factor (TNF) augments intestinal epithelial long MLCK expression, which is critical to cytoskeletal regulation. We found that TNF increases long MLCK...

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Veröffentlicht in:	The Journal of biological chemistry 2006-09, Vol.281 (36), p.26205-26215
Hauptverfasser:	Graham, W. Vallen, Wang, Fengjun, Clayburgh, Daniel R, Cheng, Jason X, Yoon, Bora, Wang, Yingmin, Lin, Anning, Turner, Jerrold R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Binding Sites Caco-2 Cells Cell Differentiation - physiology Cells, Cultured Enterocytes - cytology Enterocytes - physiology Exons Female Gene Expression Regulation Humans Interferon-gamma - metabolism Mice Mice, Inbred C57BL Molecular Sequence Data Mutagenesis, Site-Directed Myosin-Light-Chain Kinase - genetics Myosin-Light-Chain Kinase - metabolism NF-kappa B - metabolism Promoter Regions, Genetic Protein Isoforms - genetics Protein Isoforms - metabolism RNA, Messenger - metabolism Signal Transduction - physiology Transcription Factor AP-1 - metabolism Transcription, Genetic Tumor Necrosis Factor-alpha - metabolism
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