Molecular Analysis of the Interaction between the Hematopoietic Master Transcription Factors GATA-1 and PU.1

GATA-1 and PU.1 are transcription factors that control erythroid and myeloid development, respectively. The two proteins have been shown to function in an antagonistic fashion, with GATA-1 repressing PU.1 activity during erythropoiesis and PU.1 repressing GATA-1 function during myelopoiesis. It has...

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Veröffentlicht in:	The Journal of biological chemistry 2006-09, Vol.281 (38), p.28296-28306
Hauptverfasser:	Liew, Chu Wai, Rand, Kasper D., Simpson, Raina J.Y., Yung, Wendy W., Mansfield, Robyn E., Crossley, Merlin, Proetorius-Ibba, Mette, Nerlov, Claus, Poulsen, Flemming M., Mackay, Joel P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Amino Acid Motifs Amino Acid Sequence Animals Binding Sites DNA - metabolism GATA1 Transcription Factor - chemistry GATA1 Transcription Factor - physiology Hematopoiesis Humans Mice Molecular Sequence Data Phosphorylation Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - physiology Trans-Activators - chemistry Trans-Activators - physiology Zinc Fingers
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