A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses

BAFF [B cell-activating factor of the tumour necrosis factor (TNF) family] and APRIL (a proliferation-inducing ligand) are two TNF family members with shared receptors. While, physiological roles for APRIL are not fully understood, BAFF is critical for B cell homeostasis and also acts as a co-stimul...

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Veröffentlicht in:	International immunology 2006-10, Vol.18 (10), p.1473-1485
Hauptverfasser:	Huntington, Nicholas D., Tomioka, Ryo, Clavarino, Chelsea, Chow, Anne M., Liñares, David, Maña, Paula, Rossjohn, Jamie, Cachero, Teresa G., Qian, Fang, Kalled, Susan L., Bernard, Claude C. A., Reid, Hugh H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation - drug effects Antibody Formation - immunology autoimmunity B-Cell Activating Factor - antagonists & inhibitors B-Cell Activating Factor - immunology B-Cell Maturation Antigen - administration & dosage B-Lymphocytes - immunology central nervous system diseases cytokine receptors cytokines Encephalomyelitis, Autoimmune, Experimental - chemically induced Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - immunology Female Immunity, Cellular - drug effects Immunity, Cellular - immunology Immunoglobulin Fc Fragments - administration & dosage Mice Mice, Inbred NOD multiple sclerosis Multiple Sclerosis - chemically induced Multiple Sclerosis - drug therapy Multiple Sclerosis - immunology Myelin Proteins Myelin-Associated Glycoprotein - administration & dosage Myelin-Associated Glycoprotein - toxicity Myelin-Oligodendrocyte Glycoprotein Recombinant Fusion Proteins - administration & dosage T-Lymphocytes - immunology therapeutics Tumor Necrosis Factor Ligand Superfamily Member 13 - antagonists & inhibitors Tumor Necrosis Factor Ligand Superfamily Member 13 - immunology
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