Bioreversibly crosslinked polyplexes of PEI and high molecular weight PEG show extended circulation times in vivo

Copolymers consisting of branched PEI 25 kDa grafted with high molecular weight PEG at a low degree of substitution were successfully synthesized using a simple two-step procedure. The resulting AB-type and ABA-type copolymers were tested for cytotoxicity and DNA condensation and complexation proper...

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Veröffentlicht in:	Journal of controlled release 2007-12, Vol.124 (1), p.69-80
Hauptverfasser:	Neu, Michael, Germershaus, Oliver, Behe, Martin, Kissel, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatible Materials - administration & dosage Biocompatible Materials - adverse effects Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry Biological and medical sciences Cell Line, Tumor Cell Survival - drug effects Cross-Linking Reagents - administration & dosage Cross-Linking Reagents - adverse effects Cross-Linking Reagents - chemical synthesis Cross-Linking Reagents - chemistry Crosslinking DNA - administration & dosage DNA - chemistry DNA - genetics Electrophoresis, Agar Gel Flow Cytometry Gene delivery Gene Transfer Techniques General pharmacology Green Fluorescent Proteins - genetics Humans Luciferases - genetics Medical sciences Microscopy, Confocal Molecular Weight Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacokinetics Pharmacology. Drug treatments Poly(ethylene glycol) Poly(ethylene imine) Polyethylene Glycols - administration & dosage Polyethylene Glycols - adverse effects Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Polyethyleneimine - administration & dosage Polyethyleneimine - adverse effects Polyethyleneimine - chemical synthesis Polyethyleneimine - chemistry Time Factors Transfection
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