Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid–induced insulin resistance

The mitochondria-associated ER membrane (MAM) is a specialized subdomain of ER that physically connects with mitochondria. Although disruption of inter-organellar crosstalk via the MAM impairs cellular homeostasis, its pathological significance in insulin resistance in type 2 diabetes mellitus remai...

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Veröffentlicht in:	Experimental cell research 2017-10, Vol.359 (1), p.86-93
Hauptverfasser:	Shinjo, Satoko, Jiang, Shuying, Nameta, Masaaki, Suzuki, Tomohiro, Kanai, Mai, Nomura, Yuta, Goda, Nobuhito
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt PKB eIF-2 Kinase - metabolism Endoplasmic reticulum (ER) Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress - drug effects Hep G2 Cells Humans Insulin - pharmacology Insulin Resistance Intracellular Membranes - drug effects Intracellular Membranes - metabolism Membrane Proteins - metabolism Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria-associated ER membrane (MAM) Mitochondrial Proteins - metabolism Organelle Palmitic Acid - pharmacology Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Reactive Oxygen Species - metabolism Signal Transduction - drug effects
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