Discovery of naphthyl‐N‐acylhydrazone p38α MAPK inhibitors with in vivo anti‐inflammatory and anti‐TNF‐α activity

Protein kinases constitute attractive therapeutic targets for development of new prototypes to treat different chronic diseases. Several available drugs, like tinibs, are tyrosine kinase inhibitors; meanwhile, inhibitors of serine/threonine kinases, such as mitogen‐activated protein kinase (MAPK), a...

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Veröffentlicht in:	Chemical biology & drug design 2018-02, Vol.91 (2), p.391-397
Hauptverfasser:	Freitas, Rosana H. C. N., Cordeiro, Natália M., Carvalho, Patrícia R., Alves, Marina A., Guedes, Isabella A., Valerio, Tayna S., Dardenne, Laurent E., Lima, Lídia M., Barreiro, Eliezer J., Fernandes, Patrícia D., Fraga, Carlos A. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use anti‐inflammatory Binding Sites Cell Movement - drug effects Drug Design ensemble docking Humans Hydrazones - chemistry Hydrazones - metabolism Hydrazones - pharmacology Hydrazones - therapeutic use Hydrogen Bonding Inflammation - chemically induced Inflammation - drug therapy Inflammation - veterinary Inhibitory Concentration 50 kinase inhibitor Leukocytes - cytology Leukocytes - drug effects Leukocytes - metabolism Mice Mitogen-Activated Protein Kinase 14 - antagonists & inhibitors Mitogen-Activated Protein Kinase 14 - metabolism Molecular Docking Simulation N‐acylhydrazone p38α MAPK Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - metabolism Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein Structure, Tertiary Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
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