Highly regio- and stereoselective trans-iodofluorination of ynamides enabling the synthesis of (E)-α-fluoro-β-iodoenamides

Highly regio- and stereoselective trans-iodofluorination of ynamides enabling the synthesis of (E)-α-fluoro-β-iodoenamides

A highly regio- and stereoselective trans-iodofluorination reaction of ynamides with NIS and Et N·3HF has been achieved, affording (E)-α-fluoro-β-iodoenamides in moderate to good yields. The reaction proceeds under mild reaction conditions and exhibits good functional group compatibility.

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Veröffentlicht in:Organic & biomolecular chemistry 2017-08, Vol.15 (34), p.7218-7226
Hauptverfasser: Xi, Yang, Zhu, Guohao, Tang, Luning, Ma, Shihan, Zhang, Dongming, Zhang, Rong, He, Guangke, Zhu, Hongjun
Format: Artikel
Sprache:eng
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Zusammenfassung:A highly regio- and stereoselective trans-iodofluorination reaction of ynamides with NIS and Et N·3HF has been achieved, affording (E)-α-fluoro-β-iodoenamides in moderate to good yields. The reaction proceeds under mild reaction conditions and exhibits good functional group compatibility.
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob01470h