Selected Alkylating Agents Can Overcome Drug Tolerance of G0-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice

Purpose: We aimed to characterize and target drug-tolerant BRCA1-deficient tumor cells that cause residual disease and subsequent tumor relapse. Experimental Design: We studied responses to various mono- and bifunctional alkylating agents in a genetically engineered mouse model for BRCA1/p53-mutant...

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Veröffentlicht in:	Clinical cancer research 2017-11, Vol.23 (22), p.7020-7033
Hauptverfasser:	Pajic, Marina, Blatter, Sohvi, Guyader, Charlotte, Gonggrijp, Maaike, Kersbergen, Ariena, Küçükosmanoğlu, Aslι, Sol, Wendy, Drost, Rinske, Jonkers, Jos, Borst, Piet, Rottenberg, Sven
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating agents Alkylation BRCA1 protein Breast cancer Cancer Cisplatin Clonal deletion Crosslinking Deoxyribonucleic acid DNA Drug tolerance Drugs Experimental design Fluorescence Gene deletion Genetic engineering p53 Protein Platinum Restoration Tumor cells Tumors Ubiquitination
Online-Zugang:	Volltext
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