Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthases that limits nitric oxide bioavailability. Dimethylarginine dimethylaminohydrolase-1 (DDAH1) exerts a critical role for ADMA degradation and plays an important role in NO signaling. In the heart, DDAH1 is observed...

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Veröffentlicht in:	Basic research in cardiology 2017-09, Vol.112 (5), p.55-55
Hauptverfasser:	Xu, Xin, Zhang, Ping, Kwak, Dongmin, Fassett, John, Yue, Wenhui, Atzler, Dorothee, Hu, Xinli, Liu, Xiaohong, Wang, Huan, Lu, Zhongbing, Guo, Haipeng, Schwedhelm, Edzard, Böger, Rainer H., Chen, Peijie, Chen, Yingjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Amidohydrolases - deficiency Amidohydrolases - genetics Amidohydrolases - metabolism Animals Aorta Arginine - analogs & derivatives Arginine - blood Atrial Natriuretic Factor - metabolism Bioavailability Cardiology Cardiomyocytes Degradation Dimethylargininase Disease Models, Animal Endothelial cells Eutrophication Fibrosis Genetic Predisposition to Disease Heart Heart diseases Homeostasis Hypertrophy Hypertrophy, Left Ventricular - enzymology Hypertrophy, Left Ventricular - genetics Hypertrophy, Left Ventricular - physiopathology Hypertrophy, Left Ventricular - prevention & control Male Medicine Medicine & Public Health Mice Mice, Knockout Myocytes, Cardiac - enzymology Myocytes, Cardiac - pathology Nitric oxide Nitric Oxide - metabolism Nitrotyrosine Original Contribution Phenotype Plasmas (physics) Rodents Sarcolemma Signal Transduction Stresses Tyrosine - analogs & derivatives Tyrosine - metabolism Ventricle Ventricular Dysfunction, Left - enzymology Ventricular Dysfunction, Left - genetics Ventricular Dysfunction, Left - physiopathology Ventricular Dysfunction, Left - prevention & control Ventricular Function, Left Ventricular Remodeling
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