The immunophilin ligand GPI1046 protects neurons from the lethal effects of the HIV‐1 proteins gp120 and Tat by modulating endoplasmic reticulum calcium load

The dysfunction and death of neuronal cells is thought to underlie the cognitive manifestations of human immunodeficiency virus (HIV)‐associated neurological disorders. Although HIV‐infected patients are living longer owing to the effectiveness of anti‐retroviral therapies, the number of patients de...

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Veröffentlicht in:	Journal of neurochemistry 2006-07, Vol.98 (1), p.146-155
Hauptverfasser:	Caporello, Emily, Nath, Avindra, Slevin, John, Galey, David, Hamilton, Greg, Williams, Larry, Steiner, Joseph P., Haughey, Norman J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences calcium Calcium - metabolism Cell Survival - drug effects Cells, Cultured Cerebral Cortex - cytology Drug Interactions Embryo, Mammalian Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Gene Products, tat - toxicity gp120 GPI1046 HIV HIV Envelope Protein gp120 - toxicity Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases inositol 1,4,5 trisphosphate Medical sciences Neurological disorders Neurons Neurons - drug effects Neurons - ultrastructure Neurons - virology Proteins Pyrrolidines - pharmacology Rats Rats, Sprague-Dawley ryanodine Tat Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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