Isodomoic acids A and C exhibit low KA receptor affinity and reduced in vitro potency relative to domoic acid in region CA1 of rat hippocampus

Several natural isomers of the seizurogenic neurotoxin domoic acid (DA) have been found to occur at up to mg/kg levels in shellfish. The aim of the current study was to assess the neurotoxic potency of isodomoic acids A and C (Iso-A and Iso-C), recently isolated from commercial shellfish. Hippocampa...

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Veröffentlicht in:	Toxicon (Oxford) 2007-10, Vol.50 (5), p.627-638
Hauptverfasser:	Sawant, P.M., Weare, B.A., Holland, P.T., Selwood, A.I., King, K.L., Mikulski, C.M., Doucette, G.J., Mountfort, D.O., Kerr, D.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Biological and medical sciences Domoic acid Dose-Response Relationship, Drug Drug Tolerance Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Heptanoic Acids - pharmacology Hippocampal slice Hippocampus - drug effects Hippocampus - metabolism In vitro preconditioning Isodomoic acid A Isodomoic acid C Isomerism KA receptor affinity Kainic Acid - analogs & derivatives Kainic Acid - pharmacology Male Marine Toxins - pharmacology Medical sciences Neurotoxins - pharmacology Organ Culture Techniques Plant poisons toxicology Rats Rats, Wistar Receptors, Kainic Acid - metabolism Toxicology
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